3eqb
From Proteopedia
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[[Image:3eqb.png|left|200px]] | [[Image:3eqb.png|left|200px]] | ||
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{{STRUCTURE_3eqb| PDB=3eqb | SCENE= }} | {{STRUCTURE_3eqb| PDB=3eqb | SCENE= }} | ||
===X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP=== | ===X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP=== | ||
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{{ABSTRACT_PUBMED_18951019}} | {{ABSTRACT_PUBMED_18951019}} | ||
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==See Also== | ==See Also== | ||
| - | *[[Mitogen-activated protein kinase kinase]] | + | *[[Mitogen-activated protein kinase kinase|Mitogen-activated protein kinase kinase]] |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:018951019</ref><ref group="xtra">PMID:017880056</ref><ref group="xtra">PMID:015543157</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Mitogen-activated protein kinase kinase]] | [[Category: Mitogen-activated protein kinase kinase]] | ||
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[[Category: Pavlovsky, A.]] | [[Category: Pavlovsky, A.]] | ||
[[Category: Zhang, E.]] | [[Category: Zhang, E.]] | ||
| - | [[Category: Acetylation]] | ||
[[Category: Atp-binding]] | [[Category: Atp-binding]] | ||
[[Category: Disease mutation]] | [[Category: Disease mutation]] | ||
Revision as of 12:18, 25 July 2012
Contents |
X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP
Template:ABSTRACT PUBMED 18951019
About this Structure
3eqb is a 1 chain structure of Mitogen-activated protein kinase kinase with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Warmus JS, Flamme C, Zhang LY, Barrett S, Bridges A, Chen H, Gowan R, Kaufman M, Sebolt-Leopold J, Leopold W, Merriman R, Ohren J, Pavlovsky A, Przybranowski S, Tecle H, Valik H, Whitehead C, Zhang E. 2-Alkylamino- and alkoxy-substituted 2-amino-1,3,4-oxadiazoles-O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against MEK (MAP ERK kinase). Bioorg Med Chem Lett. 2008 Dec 1;18(23):6171-4. Epub 2008 Oct 7. PMID:18951019 doi:10.1016/j.bmcl.2008.10.015
- Spicer JA, Rewcastle GW, Kaufman MD, Black SL, Plummer MS, Denny WA, Quin J 3rd, Shahripour AB, Barrett SD, Whitehead CE, Milbank JB, Ohren JF, Gowan RC, Omer C, Camp HS, Esmaeil N, Moore K, Sebolt-Leopold JS, Pryzbranowski S, Merriman RL, Ortwine DF, Warmus JS, Flamme CM, Pavlovsky AG, Tecle H. 4-anilino-5-carboxamido-2-pyridone derivatives as noncompetitive inhibitors of mitogen-activated protein kinase kinase. J Med Chem. 2007 Oct 18;50(21):5090-102. Epub 2007 Sep 19. PMID:17880056 doi:10.1021/jm0704548
- Ohren JF, Chen H, Pavlovsky A, Whitehead C, Zhang E, Kuffa P, Yan C, McConnell P, Spessard C, Banotai C, Mueller WT, Delaney A, Omer C, Sebolt-Leopold J, Dudley DT, Leung IK, Flamme C, Warmus J, Kaufman M, Barrett S, Tecle H, Hasemann CA. Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition. Nat Struct Mol Biol. 2004 Dec;11(12):1192-7. Epub 2004 Nov 14. PMID:15543157 doi:10.1038/nsmb859
Categories: Homo sapiens | Mitogen-activated protein kinase kinase | Ohren, J F. | Pavlovsky, A. | Zhang, E. | Atp-binding | Disease mutation | Kinase | Ligand and mgatp | Ligand co-complex | Mitogen activated protein kinase kinase | Non-competitive protein kinase inhibitor | Nucleotide-binding | Phosphoprotein | Protein kinase structure | Serine/threonine-protein kinase | Signal transduction | Ternary co-complex with kinase | Transferase | Tyrosine-protein kinase
