1aq1
From Proteopedia
| Line 4: | Line 4: | ||
==Overview== | ==Overview== | ||
| - | Staurosporine exhibits nanomolar IC50 values against a wide range of | + | Staurosporine exhibits nanomolar IC50 values against a wide range of protein kinases. The structure of a CDK2 staurosporine complex explains the tight binding of this inhibitor, and suggests features to be exploited in the design of specific inhibitors of CDKs. |
==About this Structure== | ==About this Structure== | ||
| Line 13: | Line 13: | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Transferred entry: 2 | + | [[Category: Transferred entry: 2 7.11 1]] |
| - | [[Category: Brown, N | + | [[Category: Brown, N R.]] |
| - | [[Category: Endicott, J | + | [[Category: Endicott, J A.]] |
| - | [[Category: Johnson, L | + | [[Category: Johnson, L N.]] |
[[Category: Lawrie, A.]] | [[Category: Lawrie, A.]] | ||
| - | [[Category: Noble, M | + | [[Category: Noble, M E.M.]] |
[[Category: Tunnah, P.]] | [[Category: Tunnah, P.]] | ||
[[Category: STU]] | [[Category: STU]] | ||
| Line 29: | Line 29: | ||
[[Category: staurosporine]] | [[Category: staurosporine]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:47:08 2008'' |
Revision as of 09:47, 21 February 2008
|
HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR STAUROSPORINE
Overview
Staurosporine exhibits nanomolar IC50 values against a wide range of protein kinases. The structure of a CDK2 staurosporine complex explains the tight binding of this inhibitor, and suggests features to be exploited in the design of specific inhibitors of CDKs.
About this Structure
1AQ1 is a Single protein structure of sequence from Homo sapiens with as ligand. Active as Transferred entry: 2.7.11.1, with EC number 2.7.1.37 Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2., Lawrie AM, Noble ME, Tunnah P, Brown NR, Johnson LN, Endicott JA, Nat Struct Biol. 1997 Oct;4(10):796-801. PMID:9334743
Page seeded by OCA on Thu Feb 21 11:47:08 2008
