1aum
From Proteopedia
(New page: 200px<br /> <applet load="1aum" size="450" color="white" frame="true" align="right" spinBox="true" caption="1aum, resolution 3.0Å" /> '''HIV CAPSID C-TERMINA...) |
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| - | [[Image:1aum.gif|left|200px]]<br /> | + | [[Image:1aum.gif|left|200px]]<br /><applet load="1aum" size="350" color="white" frame="true" align="right" spinBox="true" |
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caption="1aum, resolution 3.0Å" /> | caption="1aum, resolution 3.0Å" /> | ||
'''HIV CAPSID C-TERMINAL DOMAIN (CAC146)'''<br /> | '''HIV CAPSID C-TERMINAL DOMAIN (CAC146)'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The carboxyl-terminal domain, residues 146 to 231, of the human | + | The carboxyl-terminal domain, residues 146 to 231, of the human immunodeficiency virus-1 (HIV-1) capsid protein [CA(146-231)] is required for capsid dimerization and viral assembly. This domain contains a stretch of 20 residues, called the major homology region (MHR), which is conserved across retroviruses and is essential for viral assembly, maturation, and infectivity. The crystal structures of CA(146-231) and CA(151-231) reveal that the globular domain is composed of four helices and an extended amino-terminal strand. CA(146-231) dimerizes through parallel packing of helix 2 across a dyad. The MHR is distinct from the dimer interface and instead forms an intricate hydrogen-bonding network that interconnects strand 1 and helices 1 and 2. Alignment of the CA(146-231) dimer with the crystal structure of the capsid amino-terminal domain provides a model for the intact protein and extends models for assembly of the central conical core of HIV-1. |
==About this Structure== | ==About this Structure== | ||
| - | 1AUM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http:// | + | 1AUM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AUM OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Human immunodeficiency virus 1]] | [[Category: Human immunodeficiency virus 1]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Gamble, T | + | [[Category: Gamble, T R.]] |
| - | [[Category: Hill, C | + | [[Category: Hill, C P.]] |
| - | [[Category: Mccutcheon, J | + | [[Category: Mccutcheon, J P.]] |
| - | [[Category: Schwedler, U | + | [[Category: Schwedler, U K.Von.]] |
| - | [[Category: Sundquist, W | + | [[Category: Sundquist, W I.]] |
| - | [[Category: Vajdos, F | + | [[Category: Vajdos, F F.]] |
[[Category: Wang, H.]] | [[Category: Wang, H.]] | ||
| - | [[Category: Worthylake, D | + | [[Category: Worthylake, D K.]] |
[[Category: Yoo, S.]] | [[Category: Yoo, S.]] | ||
[[Category: c-terminal domain]] | [[Category: c-terminal domain]] | ||
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[[Category: hiv]] | [[Category: hiv]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:48:23 2008'' |
Revision as of 09:48, 21 February 2008
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HIV CAPSID C-TERMINAL DOMAIN (CAC146)
Overview
The carboxyl-terminal domain, residues 146 to 231, of the human immunodeficiency virus-1 (HIV-1) capsid protein [CA(146-231)] is required for capsid dimerization and viral assembly. This domain contains a stretch of 20 residues, called the major homology region (MHR), which is conserved across retroviruses and is essential for viral assembly, maturation, and infectivity. The crystal structures of CA(146-231) and CA(151-231) reveal that the globular domain is composed of four helices and an extended amino-terminal strand. CA(146-231) dimerizes through parallel packing of helix 2 across a dyad. The MHR is distinct from the dimer interface and instead forms an intricate hydrogen-bonding network that interconnects strand 1 and helices 1 and 2. Alignment of the CA(146-231) dimer with the crystal structure of the capsid amino-terminal domain provides a model for the intact protein and extends models for assembly of the central conical core of HIV-1.
About this Structure
1AUM is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.
Reference
Structure of the carboxyl-terminal dimerization domain of the HIV-1 capsid protein., Gamble TR, Yoo S, Vajdos FF, von Schwedler UK, Worthylake DK, Wang H, McCutcheon JP, Sundquist WI, Hill CP, Science. 1997 Oct 31;278(5339):849-53. PMID:9346481
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