3orn
From Proteopedia
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[[Image:3orn.png|left|200px]] | [[Image:3orn.png|left|200px]] | ||
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{{STRUCTURE_3orn| PDB=3orn | SCENE= }} | {{STRUCTURE_3orn| PDB=3orn | SCENE= }} | ||
===Mitogen-activated protein kinase kinase 1 (MEK1) in complex with CH4987655 and MgAMP-PNP=== | ===Mitogen-activated protein kinase kinase 1 (MEK1) in complex with CH4987655 and MgAMP-PNP=== | ||
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{{ABSTRACT_PUBMED_21316218}} | {{ABSTRACT_PUBMED_21316218}} | ||
==About this Structure== | ==About this Structure== | ||
| - | [[3orn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ORN OCA]. | + | [[3orn]] is a 1 chain structure of [[Mitogen-activated protein kinase kinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ORN OCA]. |
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| + | ==See Also== | ||
| + | *[[Mitogen-activated protein kinase kinase|Mitogen-activated protein kinase kinase]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:021316218</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Mitogen-activated protein kinase kinase]] | [[Category: Mitogen-activated protein kinase kinase]] | ||
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[[Category: Lukacs, C M.]] | [[Category: Lukacs, C M.]] | ||
[[Category: Schuck, V.]] | [[Category: Schuck, V.]] | ||
| + | [[Category: Allosteric]] | ||
| + | [[Category: Kinase]] | ||
| + | [[Category: Kinase inhibitor]] | ||
| + | [[Category: Mitogen-activated protein kinase kinase]] | ||
| + | [[Category: Transferase-transferase inhibitor complex]] | ||
Revision as of 13:16, 25 July 2012
Contents |
Mitogen-activated protein kinase kinase 1 (MEK1) in complex with CH4987655 and MgAMP-PNP
Template:ABSTRACT PUBMED 21316218
About this Structure
3orn is a 1 chain structure of Mitogen-activated protein kinase kinase with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Isshiki Y, Kohchi Y, Iikura H, Matsubara Y, Asoh K, Murata T, Kohchi M, Mizuguchi E, Tsujii S, Hattori K, Miura T, Yoshimura Y, Aida S, Miwa M, Saitoh R, Murao N, Okabe H, Belunis C, Janson C, Lukacs C, Schuck V, Shimma N. Design and synthesis of novel allosteric MEK inhibitor CH4987655 as an orally available anticancer agent. Bioorg Med Chem Lett. 2011 Jan 21. PMID:21316218 doi:10.1016/j.bmcl.2011.01.062
