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1avc
From Proteopedia
(New page: 200px<br /><applet load="1avc" size="450" color="white" frame="true" align="right" spinBox="true" caption="1avc, resolution 2.90Å" /> '''BOVINE ANNEXIN VI (C...) |
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| - | [[Image:1avc.gif|left|200px]]<br /><applet load="1avc" size=" | + | [[Image:1avc.gif|left|200px]]<br /><applet load="1avc" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1avc, resolution 2.90Å" /> | caption="1avc, resolution 2.90Å" /> | ||
'''BOVINE ANNEXIN VI (CALCIUM-BOUND)'''<br /> | '''BOVINE ANNEXIN VI (CALCIUM-BOUND)'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The crystal structure of a calcium-bound form of bovine annexin VI has | + | The crystal structure of a calcium-bound form of bovine annexin VI has been determined with X-ray diffraction data to 2.9 A by molecular replacement. Six Ca2+ ions were found, five in AB loops, one in a DE loop. Two loops (II-AB, which binds calcium, and V-AB, which does not) have conformations that differ significantly from those in calcium-free, human recombinant annexin VI. There are only small differences between the calci- and the apo-annexin VI in the rest of the molecule. Calcium by itself does not promote a major conformational change. |
==About this Structure== | ==About this Structure== | ||
| - | 1AVC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with CA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1AVC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AVC OCA]. |
==Reference== | ==Reference== | ||
| Line 13: | Line 13: | ||
[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Avila-Sakar, A | + | [[Category: Avila-Sakar, A J.]] |
| - | [[Category: Creutz, C | + | [[Category: Creutz, C E.]] |
| - | [[Category: Kretsinger, R | + | [[Category: Kretsinger, R H.]] |
[[Category: CA]] | [[Category: CA]] | ||
[[Category: annexin]] | [[Category: annexin]] | ||
| Line 22: | Line 22: | ||
[[Category: membrane-binding]] | [[Category: membrane-binding]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:48:39 2008'' |
Revision as of 09:48, 21 February 2008
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BOVINE ANNEXIN VI (CALCIUM-BOUND)
Overview
The crystal structure of a calcium-bound form of bovine annexin VI has been determined with X-ray diffraction data to 2.9 A by molecular replacement. Six Ca2+ ions were found, five in AB loops, one in a DE loop. Two loops (II-AB, which binds calcium, and V-AB, which does not) have conformations that differ significantly from those in calcium-free, human recombinant annexin VI. There are only small differences between the calci- and the apo-annexin VI in the rest of the molecule. Calcium by itself does not promote a major conformational change.
About this Structure
1AVC is a Single protein structure of sequence from Bos taurus with as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of bovine annexin VI in a calcium-bound state., Avila-Sakar AJ, Creutz CE, Kretsinger RH, Biochim Biophys Acta. 1998 Sep 8;1387(1-2):103-16. PMID:9748523
Page seeded by OCA on Thu Feb 21 11:48:39 2008
