2nru
From Proteopedia
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[[Image:2nru.png|left|200px]] | [[Image:2nru.png|left|200px]] | ||
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{{STRUCTURE_2nru| PDB=2nru | SCENE= }} | {{STRUCTURE_2nru| PDB=2nru | SCENE= }} | ||
===Crystal structure of IRAK-4=== | ===Crystal structure of IRAK-4=== | ||
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{{ABSTRACT_PUBMED_17161373}} | {{ABSTRACT_PUBMED_17161373}} | ||
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| - | ==Disease== | ||
| - | Known disease associated with this structure: IRAK4 deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=606883 606883]], Invasive pneumococcal disease, recurrent isolated, 1 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=606883 606883]] | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[2nru]] is a 4 chain structure of [[Interleukin-1 receptor-associated kinase 4]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NRU OCA]. | |
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| + | ==See Also== | ||
| + | *[[Interleukin-1 receptor-associated kinase 4|Interleukin-1 receptor-associated kinase 4]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:017161373</ref><ref group="xtra">PMID:020485341</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Non-specific serine/threonine protein kinase]] | [[Category: Non-specific serine/threonine protein kinase]] | ||
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[[Category: Irak]] | [[Category: Irak]] | ||
[[Category: Kinase]] | [[Category: Kinase]] | ||
| - | + | [[Category: Transferase]] | |
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Revision as of 14:00, 25 July 2012
Contents |
Crystal structure of IRAK-4
Template:ABSTRACT PUBMED 17161373
About this Structure
2nru is a 4 chain structure of Interleukin-1 receptor-associated kinase 4 with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Wang Z, Liu J, Sudom A, Ayres M, Li S, Wesche H, Powers JP, Walker NP. Crystal structures of IRAK-4 kinase in complex with inhibitors: a serine/threonine kinase with tyrosine as a gatekeeper. Structure. 2006 Dec;14(12):1835-44. PMID:17161373 doi:10.1016/j.str.2006.11.001
- Lin SC, Lo YC, Wu H. Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling. Nature. 2010 Jun 17;465(7300):885-90. Epub 2010 May 19. PMID:20485341 doi:10.1038/nature09121
