1gux

(Difference between revisions)

Revision as of 14:19, 25 July 2012

1gux, resolution 1.85Å ()

Structural annotation:
Resources:	CATH : 1Guxa00, 1Guxb00 InterPro : Ipr015030, Ipr011028, Ipr013763, Ipr015652, Ipr006670, Ipr002720, Ipr002719 Pfam : PF01858, PF08934, PF01857 SCOP : d1guxa_, d1guxb_ UniProt : P06400

Functional annotation:
Cellular component:	nucleus PML body chromatin
Biological process:	regulation of lipid kinase activity negative regulation of cell growth regulation of transcription, DNA-dependent cell cycle checkpoint cell cycle positive regulation of transcription, DNA-dependent negative regulation of transcription from RNA polymerase II promoter transcription chromatin modification negative regulation of protein kinase activity negative regulation of cell cycle M phase androgen receptor signaling pathway G1 phase
Molecular function:	protein binding transcription coactivator activity DNA binding transcription factor activity kinase binding androgen receptor binding

Evolutionary conservation:

Toggle Conservation Colors:

Rows = identical sequences:

Further Information:

Caveats,

Resources:

FirstGlance, OCA, RCSB, PDBsum

Coordinates:

save as pdb, mmCIF, xml

1gux is a 3 chain structure of Retinoblastoma protein with sequence from Homo sapiens and Human papillomavirus. Full crystallographic information is available from OCA.

Lee JO, Russo AA, Pavletich NP. Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7. Nature. 1998 Feb 26;391(6670):859-65. PMID:9495340 doi:10.1038/36038