1b2v
From Proteopedia
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==Overview== | ==Overview== | ||
| - | Free iron availability is strongly limited in vertebrate hosts, making the | + | Free iron availability is strongly limited in vertebrate hosts, making the iron acquisition by siderophores inappropriate. Pathogenic bacteria have developed various ways to use the host's iron from iron-containing proteins. Serratia marcescens can use the iron from hemoglobin through the secretion of a hemophore called HasA, which takes up the heme from hemoglobin and shuttles it to the receptor HasR, which in turn, releases heme into the bacterium. We report here the first crystal structure of such a hemophore, bound to a heme group at two different pH values and at a resolution of 1.9 A. The structure reveals a new original fold and suggests a hypothetical mechanism for both heme uptake and release. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Izadi, N.]] | [[Category: Izadi, N.]] | ||
[[Category: Lecroisey, A.]] | [[Category: Lecroisey, A.]] | ||
| - | [[Category: Wandersma, N | + | [[Category: Wandersma, N C.]] |
[[Category: CA]] | [[Category: CA]] | ||
[[Category: HEM]] | [[Category: HEM]] | ||
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[[Category: iron metabolism]] | [[Category: iron metabolism]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:50:51 2008'' |
Revision as of 09:50, 21 February 2008
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HEME-BINDING PROTEIN A
Overview
Free iron availability is strongly limited in vertebrate hosts, making the iron acquisition by siderophores inappropriate. Pathogenic bacteria have developed various ways to use the host's iron from iron-containing proteins. Serratia marcescens can use the iron from hemoglobin through the secretion of a hemophore called HasA, which takes up the heme from hemoglobin and shuttles it to the receptor HasR, which in turn, releases heme into the bacterium. We report here the first crystal structure of such a hemophore, bound to a heme group at two different pH values and at a resolution of 1.9 A. The structure reveals a new original fold and suggests a hypothetical mechanism for both heme uptake and release.
About this Structure
1B2V is a Single protein structure of sequence from Serratia marcescens with and as ligands. Full crystallographic information is available from OCA.
Reference
The crystal structure of HasA, a hemophore secreted by Serratia marcescens., Arnoux P, Haser R, Izadi N, Lecroisey A, Delepierre M, Wandersman C, Czjzek M, Nat Struct Biol. 1999 Jun;6(6):516-20. PMID:10360351
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