1b4f
From Proteopedia
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==Overview== | ==Overview== | ||
| - | The sterile alpha motif (SAM) domain is a protein interaction module that | + | The sterile alpha motif (SAM) domain is a protein interaction module that is present in diverse signal-transducing proteins. SAM domains are known to form homo- and hetero-oligomers. The crystal structure of the SAM domain from an Eph receptor tyrosine kinase, EphB2, reveals two large interfaces. In one interface, adjacent monomers exchange amino-terminal peptides that insert into a hydrophobic groove on each neighbor. A second interface is composed of the carboxyl-terminal helix and a nearby loop. A possible oligomer, constructed from a combination of these binding modes, may provide a platform for the formation of larger protein complexes. |
==Disease== | ==Disease== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Bowie, J | + | [[Category: Bowie, J U.]] |
| - | [[Category: Goodwill, K | + | [[Category: Goodwill, K E.]] |
| - | [[Category: Thanos, C | + | [[Category: Thanos, C D.]] |
[[Category: eph receptor]] | [[Category: eph receptor]] | ||
[[Category: oligomer]] | [[Category: oligomer]] | ||
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[[Category: signal transduction]] | [[Category: signal transduction]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:51:21 2008'' |
Revision as of 09:51, 21 February 2008
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OLIGOMERIC STRUCTURE OF THE HUMAN EPHB2 RECEPTOR SAM DOMAIN
Contents |
Overview
The sterile alpha motif (SAM) domain is a protein interaction module that is present in diverse signal-transducing proteins. SAM domains are known to form homo- and hetero-oligomers. The crystal structure of the SAM domain from an Eph receptor tyrosine kinase, EphB2, reveals two large interfaces. In one interface, adjacent monomers exchange amino-terminal peptides that insert into a hydrophobic groove on each neighbor. A second interface is composed of the carboxyl-terminal helix and a nearby loop. A possible oligomer, constructed from a combination of these binding modes, may provide a platform for the formation of larger protein complexes.
Disease
Known diseases associated with this structure: Prostate cancer, progression and metastasis of OMIM:[600997]
About this Structure
1B4F is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Oligomeric structure of the human EphB2 receptor SAM domain., Thanos CD, Goodwill KE, Bowie JU, Science. 1999 Feb 5;283(5403):833-6. PMID:9933164
Page seeded by OCA on Thu Feb 21 11:51:21 2008
