2rh1
From Proteopedia
m (Protected "2rh1" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
[[Image:2rh1.png|left|200px]] | [[Image:2rh1.png|left|200px]] | ||
| - | <!-- | ||
| - | The line below this paragraph, containing "STRUCTURE_2rh1", creates the "Structure Box" on the page. | ||
| - | You may change the PDB parameter (which sets the PDB file loaded into the applet) | ||
| - | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | ||
| - | or leave the SCENE parameter empty for the default display. | ||
| - | --> | ||
{{STRUCTURE_2rh1| PDB=2rh1 | SCENE= }} | {{STRUCTURE_2rh1| PDB=2rh1 | SCENE= }} | ||
===High resolution crystal structure of human B2-adrenergic G protein-coupled receptor.=== | ===High resolution crystal structure of human B2-adrenergic G protein-coupled receptor.=== | ||
| - | |||
| - | <!-- | ||
| - | The line below this paragraph, {{ABSTRACT_PUBMED_17962520}}, adds the Publication Abstract to the page | ||
| - | (as it appears on PubMed at http://www.pubmed.gov), where 17962520 is the PubMed ID number. | ||
| - | --> | ||
{{ABSTRACT_PUBMED_17962520}} | {{ABSTRACT_PUBMED_17962520}} | ||
==About this Structure== | ==About this Structure== | ||
| - | [[2rh1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens,_enterobacteria_phage_t4 Homo sapiens, enterobacteria phage t4]. The April 2008 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Adrenergic Receptors'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2008_4 10.2210/rcsb_pdb/mom_2008_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RH1 OCA]. | + | [[2rh1]] is a 1 chain structure of [[Adrenergic receptor]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens,_enterobacteria_phage_t4 Homo sapiens, enterobacteria phage t4]. The April 2008 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Adrenergic Receptors'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2008_4 10.2210/rcsb_pdb/mom_2008_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RH1 OCA]. |
==See Also== | ==See Also== | ||
| - | *[[ | + | *[[Adrenergic receptor|Adrenergic receptor]] |
| - | *[[ | + | *[[Beta-2 Adrenergic Receptor|Beta-2 Adrenergic Receptor]] |
| - | *[[ | + | *[[Suggestions for new articles|Suggestions for new articles]] |
| - | *[[User: | + | *[[User:Wayne Decatur/NASCE2011|User:Wayne Decatur/NASCE2011]] |
==Reference== | ==Reference== | ||
| Line 54: | Line 43: | ||
[[Category: Lipidic cubic phase]] | [[Category: Lipidic cubic phase]] | ||
[[Category: Membrane protein]] | [[Category: Membrane protein]] | ||
| - | [[Category: Membrane protein | + | [[Category: Membrane protein - hydrolase complex]] |
[[Category: Mesophase]] | [[Category: Mesophase]] | ||
[[Category: Protein structure initiative]] | [[Category: Protein structure initiative]] | ||
[[Category: Psi-2]] | [[Category: Psi-2]] | ||
[[Category: Structural genomic]] | [[Category: Structural genomic]] | ||
Revision as of 16:01, 25 July 2012
| |||||||||
| 2rh1, resolution 2.40Å () | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Ligands: | , , , , , , , | ||||||||
| Gene: | ADRB2, ADRB2R, B2AR / E (Enterobacteria phage T4) | ||||||||
| |||||||||
| |||||||||
| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Contents |
High resolution crystal structure of human B2-adrenergic G protein-coupled receptor.
Heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors constitute the largest family of eukaryotic signal transduction proteins that communicate across the membrane. We report the crystal structure of a human beta2-adrenergic receptor-T4 lysozyme fusion protein bound to the partial inverse agonist carazolol at 2.4 angstrom resolution. The structure provides a high-resolution view of a human G protein-coupled receptor bound to a diffusible ligand. Ligand-binding site accessibility is enabled by the second extracellular loop, which is held out of the binding cavity by a pair of closely spaced disulfide bridges and a short helical segment within the loop. Cholesterol, a necessary component for crystallization, mediates an intriguing parallel association of receptor molecules in the crystal lattice. Although the location of carazolol in the beta2-adrenergic receptor is very similar to that of retinal in rhodopsin, structural differences in the ligand-binding site and other regions highlight the challenges in using rhodopsin as a template model for this large receptor family.
High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor., Cherezov V, Rosenbaum DM, Hanson MA, Rasmussen SG, Thian FS, Kobilka TS, Choi HJ, Kuhn P, Weis WI, Kobilka BK, Stevens RC, Science. 2007 Nov 23;318(5854):1258-65. Epub 2007 Oct 25. PMID:17962520
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
2rh1 is a 1 chain structure of Adrenergic receptor with sequence from Homo sapiens, enterobacteria phage t4. The April 2008 RCSB PDB Molecule of the Month feature on Adrenergic Receptors by David S. Goodsell is 10.2210/rcsb_pdb/mom_2008_4. Full crystallographic information is available from OCA.
See Also
- Adrenergic receptor
- Beta-2 Adrenergic Receptor
- Suggestions for new articles
- User:Wayne Decatur/NASCE2011
Reference
- Cherezov V, Rosenbaum DM, Hanson MA, Rasmussen SG, Thian FS, Kobilka TS, Choi HJ, Kuhn P, Weis WI, Kobilka BK, Stevens RC. High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor. Science. 2007 Nov 23;318(5854):1258-65. Epub 2007 Oct 25. PMID:17962520
- Rosenbaum DM, Cherezov V, Hanson MA, Rasmussen SG, Thian FS, Kobilka TS, Choi HJ, Yao XJ, Weis WI, Stevens RC, Kobilka BK. GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function. Science. 2007 Nov 23;318(5854):1266-73. Epub 2007 Oct 25. PMID:17962519
Categories: Adrenergic Receptors | Homo sapiens, enterobacteria phage t4 | RCSB PDB Molecule of the Month | ATCG3D, Accelerated Technologies Center for Gene to 3D Structure. | Cherezov, V. | Choi, H J. | Hanson, M A. | Kobilka, B K. | Kobilka, T S. | Kuhn, P. | Rasmussen, S G.F. | Rosenbaum, D M. | Stevens, R C. | Thian, F S. | Weis, W I. | 7tm | Accelerated technologies center for gene to 3d structure | Adrenergic | Atcg3d | Cholesterol | Fusion | Gpcr | Lipidic | Lipidic cubic phase | Membrane protein | Membrane protein - hydrolase complex | Mesophase | Protein structure initiative | Psi-2 | Structural genomic
