2ofu
From Proteopedia
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[[Image:2ofu.png|left|200px]] | [[Image:2ofu.png|left|200px]] | ||
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{{STRUCTURE_2ofu| PDB=2ofu | SCENE= }} | {{STRUCTURE_2ofu| PDB=2ofu | SCENE= }} | ||
===x-ray crystal structure of 2-aminopyrimidine carbamate 43 bound to Lck=== | ===x-ray crystal structure of 2-aminopyrimidine carbamate 43 bound to Lck=== | ||
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{{ABSTRACT_PUBMED_16884310}} | {{ABSTRACT_PUBMED_16884310}} | ||
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| - | ==Disease== | ||
| - | Known disease associated with this structure: SCID due to LCK deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=153390 153390]] | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[2ofu]] is a 1 chain structure of [[Proto-oncogene tyrosine-protein kinase]] and [[Tyrosine kinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OFU OCA]. | |
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| + | ==See Also== | ||
| + | *[[Proto-oncogene tyrosine-protein kinase|Proto-oncogene tyrosine-protein kinase]] | ||
| + | *[[Tyrosine kinase|Tyrosine kinase]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:016884310</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Non-specific protein-tyrosine kinase]] | [[Category: Non-specific protein-tyrosine kinase]] | ||
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[[Category: Kinase domain]] | [[Category: Kinase domain]] | ||
[[Category: Lck]] | [[Category: Lck]] | ||
| - | + | [[Category: Transferase]] | |
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Revision as of 16:32, 25 July 2012
Contents |
x-ray crystal structure of 2-aminopyrimidine carbamate 43 bound to Lck
Template:ABSTRACT PUBMED 16884310
About this Structure
2ofu is a 1 chain structure of Proto-oncogene tyrosine-protein kinase and Tyrosine kinase with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Martin MW, Newcomb J, Nunes JJ, McGowan DC, Armistead DM, Boucher C, Buchanan JL, Buckner W, Chai L, Elbaum D, Epstein LF, Faust T, Flynn S, Gallant P, Gore A, Gu Y, Hsieh F, Huang X, Lee JH, Metz D, Middleton S, Mohn D, Morgenstern K, Morrison MJ, Novak PM, Oliveira-dos-Santos A, Powers D, Rose P, Schneider S, Sell S, Tudor Y, Turci SM, Welcher AA, White RD, Zack D, Zhao H, Zhu L, Zhu X, Ghiron C, Amouzegh P, Ermann M, Jenkins J, Johnston D, Napier S, Power E. Novel 2-aminopyrimidine carbamates as potent and orally active inhibitors of Lck: synthesis, SAR, and in vivo antiinflammatory activity. J Med Chem. 2006 Aug 10;49(16):4981-91. PMID:16884310 doi:10.1021/jm060435i
