2ofu

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Revision as of 16:32, 25 July 2012

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Template:STRUCTURE 2ofu

Contents 1 x-ray crystal structure of 2-aminopyrimidine carbamate 43 bound to Lck 2 About this Structure 3 See Also 4 Reference

x-ray crystal structure of 2-aminopyrimidine carbamate 43 bound to Lck

Template:ABSTRACT PUBMED 16884310

About this Structure

2ofu is a 1 chain structure of Proto-oncogene tyrosine-protein kinase and Tyrosine kinase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• Proto-oncogene tyrosine-protein kinase
• Tyrosine kinase

Reference

• Martin MW, Newcomb J, Nunes JJ, McGowan DC, Armistead DM, Boucher C, Buchanan JL, Buckner W, Chai L, Elbaum D, Epstein LF, Faust T, Flynn S, Gallant P, Gore A, Gu Y, Hsieh F, Huang X, Lee JH, Metz D, Middleton S, Mohn D, Morgenstern K, Morrison MJ, Novak PM, Oliveira-dos-Santos A, Powers D, Rose P, Schneider S, Sell S, Tudor Y, Turci SM, Welcher AA, White RD, Zack D, Zhao H, Zhu L, Zhu X, Ghiron C, Amouzegh P, Ermann M, Jenkins J, Johnston D, Napier S, Power E. Novel 2-aminopyrimidine carbamates as potent and orally active inhibitors of Lck: synthesis, SAR, and in vivo antiinflammatory activity. J Med Chem. 2006 Aug 10;49(16):4981-91. PMID:16884310 doi:10.1021/jm060435i