2of2
From Proteopedia
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[[Image:2of2.png|left|200px]] | [[Image:2of2.png|left|200px]] | ||
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{{STRUCTURE_2of2| PDB=2of2 | SCENE= }} | {{STRUCTURE_2of2| PDB=2of2 | SCENE= }} | ||
===crystal structure of furanopyrimidine 8 bound to lck=== | ===crystal structure of furanopyrimidine 8 bound to lck=== | ||
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{{ABSTRACT_PUBMED_17276681}} | {{ABSTRACT_PUBMED_17276681}} | ||
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| - | ==Disease== | ||
| - | Known disease associated with this structure: SCID due to LCK deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=153390 153390]] | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[2of2]] is a 1 chain structure of [[Proto-oncogene tyrosine-protein kinase]] and [[Tyrosine kinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OF2 OCA]. | |
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| + | ==See Also== | ||
| + | *[[Proto-oncogene tyrosine-protein kinase|Proto-oncogene tyrosine-protein kinase]] | ||
| + | *[[Tyrosine kinase|Tyrosine kinase]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:017276681</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Non-specific protein-tyrosine kinase]] | [[Category: Non-specific protein-tyrosine kinase]] | ||
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[[Category: Kinase domain]] | [[Category: Kinase domain]] | ||
[[Category: Lck]] | [[Category: Lck]] | ||
| - | + | [[Category: Transferase]] | |
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Revision as of 16:36, 25 July 2012
Contents |
crystal structure of furanopyrimidine 8 bound to lck
Template:ABSTRACT PUBMED 17276681
About this Structure
2of2 is a 1 chain structure of Proto-oncogene tyrosine-protein kinase and Tyrosine kinase with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Martin MW, Newcomb J, Nunes JJ, Bemis JE, McGowan DC, White RD, Buchanan JL, DiMauro EF, Boucher C, Faust T, Hsieh F, Huang X, Lee JH, Schneider S, Turci SM, Zhu X. Discovery of novel 2,3-diarylfuro[2,3-b]pyridin-4-amines as potent and selective inhibitors of Lck: synthesis, SAR, and pharmacokinetic properties. Bioorg Med Chem Lett. 2007 Apr 15;17(8):2299-304. Epub 2007 Jan 24. PMID:17276681 doi:10.1016/j.bmcl.2007.01.048
