2cea
From Proteopedia
(New page: 200px<br /> <applet load="2cea" size="450" color="white" frame="true" align="right" spinBox="true" caption="2cea, resolution 2.75Å" /> '''WILDTYPE'''<br /> ...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2CEA is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]] with ZN, MG and ADP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CEA OCA]]. | + | 2CEA is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]] with ZN, MG and ADP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CEA OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: metalloprotease]] | [[Category: metalloprotease]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:38:56 2007'' |
Revision as of 11:34, 30 October 2007
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WILDTYPE
Overview
The ATP-dependent integral membrane protease FtsH is universally conserved, in bacteria. Orthologs exist in chloroplasts and mitochondria, where in, humans the loss of a close FtsH-homolog causes a form of spastic, paraplegia. FtsH plays a crucial role in quality control by degrading, unneeded or damaged membrane proteins, but it also targets soluble, signaling factors like sigma(32) and lambda-CII. We report here the, crystal structure of a soluble FtsH construct that is functional in, caseinolytic and ATPase assays. The molecular architecture of this, hexameric molecule consists of two rings where the protease domains, possess an all-helical fold and form a flat hexagon that is covered by a, toroid built by the AAA domains. The active site of the protease, classifies FtsH as an ... [(full description)]
About this Structure
2CEA is a [Single protein] structure of sequence from [Thermotoga maritima] with ZN, MG and ADP as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
The molecular architecture of the metalloprotease FtsH., Bieniossek C, Schalch T, Bumann M, Meister M, Meier R, Baumann U, Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3066-71. Epub 2006 Feb 16. PMID:16484367
Page seeded by OCA on Tue Oct 30 13:38:56 2007
Categories: Single protein | Thermotoga maritima | Baumann, U. | Bieniossek, C. | ADP | MG | ZN | Cell division | Cell division protein | Ftsh | Metalloprotease
