3i25

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Revision as of 17:18, 25 July 2012

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Template:STRUCTURE 3i25

Contents 1 Potent Beta-Secretase 1 hydroxyethylene Inhibitor 2 About this Structure 3 See Also 4 Reference

Potent Beta-Secretase 1 hydroxyethylene Inhibitor

Template:ABSTRACT PUBMED 20122837

About this Structure

3i25 is a 3 chain structure of Beta secretase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• Beta secretase

Reference

• Bjorklund C, Adolfsson H, Jansson K, Lindberg J, Vrang L, Hallberg A, Rosenquist S, Samuelsson B. Discovery of potent BACE-1 inhibitors containing a new hydroxyethylene (HE) scaffold: exploration of P1' alkoxy residues and an aminoethylene (AE) central core. Bioorg Med Chem. 2010 Feb 15;18(4):1711-23. Epub 2010 Jan 11. PMID:20122837 doi:10.1016/j.bmc.2009.12.051