2cey
From Proteopedia
(New page: 200px<br /> <applet load="2cey" size="450" color="white" frame="true" align="right" spinBox="true" caption="2cey, resolution 1.70Å" /> '''APO STRUCTURE OF SI...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2CEY is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]] with ZN as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CEY OCA]]. | + | 2CEY is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]] with ZN as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CEY OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: virulence factor]] | [[Category: virulence factor]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:39:23 2007'' |
Revision as of 11:34, 30 October 2007
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APO STRUCTURE OF SIAP
Overview
Extracytoplasmic solute receptors (ESRs) are important components of, solute uptake systems in bacteria, having been studied extensively as, parts of ATP binding cassette transporters. Herein we report the first, crystal structure of an ESR protein from a functionally characterized, electrochemical ion gradient dependent secondary transporter. This, protein, SiaP, forms part of a tripartite ATP-independent periplasmic, transporter specific for sialic acid in Haemophilus influenzae., Surprisingly, the structure reveals an overall topology similar to ATP, binding cassette ESR proteins, which is not apparent from the sequence, demonstrating that primary and secondary transporters can share a common, structural component. The structure of SiaP in the presence of the sialic, acid analogue ... [(full description)]
About this Structure
2CEY is a [Single protein] structure of sequence from [Haemophilus influenzae] with ZN as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Conservation of structure and mechanism in primary and secondary transporters exemplified by SiaP, a sialic acid binding virulence factor from Haemophilus influenzae., Muller A, Severi E, Mulligan C, Watts AG, Kelly DJ, Wilson KS, Wilkinson AJ, Thomas GH, J Biol Chem. 2006 Aug 4;281(31):22212-22. Epub 2006 May 15. PMID:16702222
Page seeded by OCA on Tue Oct 30 13:39:23 2007
Categories: Haemophilus influenzae | Single protein | Kelly, D.J. | Muller, A. | Mulligan, C. | Severi, E. | Thomas, G.H. | Watts, A.G. | Wilkinson, A.J. | Wilson, K.S. | ZN | Esr | Neu5ac2en | Periplasmic binding protein | Sialic acid | Transport | Tripartite atp-independent periplasmic (trap) transport | Virulence factor
