1bg7

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(New page: 200px<br /><applet load="1bg7" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bg7, resolution 1.85&Aring;" /> '''LOCALIZED UNFOLDING ...)
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[[Image:1bg7.gif|left|200px]]<br /><applet load="1bg7" size="350" color="white" frame="true" align="right" spinBox="true"
caption="1bg7, resolution 1.85&Aring;" />
caption="1bg7, resolution 1.85&Aring;" />
'''LOCALIZED UNFOLDING AT THE JUNCTION OF THREE FERRITIN SUBUNITS. A MECHANISM FOR IRON RELEASE?'''<br />
'''LOCALIZED UNFOLDING AT THE JUNCTION OF THREE FERRITIN SUBUNITS. A MECHANISM FOR IRON RELEASE?'''<br />
==Overview==
==Overview==
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How and where iron exits from ferritin for cellular use is unknown., Twenty-four protein subunits create a cavity in ferritin where iron is, concentrated &gt;10(11)-fold as a mineral. Proline substitution for conserved, leucine 134 (L134P) allowed normal assembly but increased iron exit rates., X-ray crystallography of H-L134P ferritin revealed localized unfolding at, the 3-fold axis, also iron entry sites, consistent with shared use sites, for iron exit and entry. The junction of three ferritin subunits appears, to be a dynamic aperture with a "shutter" that cytoplasmic factors might, open or close to regulate iron release in vivo.
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How and where iron exits from ferritin for cellular use is unknown. Twenty-four protein subunits create a cavity in ferritin where iron is concentrated &gt;10(11)-fold as a mineral. Proline substitution for conserved leucine 134 (L134P) allowed normal assembly but increased iron exit rates. X-ray crystallography of H-L134P ferritin revealed localized unfolding at the 3-fold axis, also iron entry sites, consistent with shared use sites for iron exit and entry. The junction of three ferritin subunits appears to be a dynamic aperture with a "shutter" that cytoplasmic factors might open or close to regulate iron release in vivo.
==About this Structure==
==About this Structure==
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1BG7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rana_catesbeiana Rana catesbeiana] with CA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BG7 OCA].
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1BG7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rana_catesbeiana Rana catesbeiana] with <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BG7 OCA].
==Reference==
==Reference==
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[[Category: Rana catesbeiana]]
[[Category: Rana catesbeiana]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Allewell, N.M.]]
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[[Category: Allewell, N M.]]
[[Category: Ha, Y.]]
[[Category: Ha, Y.]]
[[Category: Shi, D.]]
[[Category: Shi, D.]]
[[Category: Takagi, H.]]
[[Category: Takagi, H.]]
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[[Category: Theil, E.C.]]
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[[Category: Theil, E C.]]
[[Category: CA]]
[[Category: CA]]
[[Category: ferritin]]
[[Category: ferritin]]
[[Category: iron storage]]
[[Category: iron storage]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 11:37:34 2007''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:54:56 2008''

Revision as of 09:54, 21 February 2008

Image:1bg7.gif

1bg7, resolution 1.85Å

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LOCALIZED UNFOLDING AT THE JUNCTION OF THREE FERRITIN SUBUNITS. A MECHANISM FOR IRON RELEASE?

Overview

How and where iron exits from ferritin for cellular use is unknown. Twenty-four protein subunits create a cavity in ferritin where iron is concentrated >10(11)-fold as a mineral. Proline substitution for conserved leucine 134 (L134P) allowed normal assembly but increased iron exit rates. X-ray crystallography of H-L134P ferritin revealed localized unfolding at the 3-fold axis, also iron entry sites, consistent with shared use sites for iron exit and entry. The junction of three ferritin subunits appears to be a dynamic aperture with a "shutter" that cytoplasmic factors might open or close to regulate iron release in vivo.

About this Structure

1BG7 is a Single protein structure of sequence from Rana catesbeiana with as ligand. Full crystallographic information is available from OCA.

Reference

Localized unfolding at the junction of three ferritin subunits. A mechanism for iron release?, Takagi H, Shi D, Ha Y, Allewell NM, Theil EC, J Biol Chem. 1998 Jul 24;273(30):18685-8. PMID:9668036

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