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2zc9
From Proteopedia
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[[Image:2zc9.png|left|200px]] | [[Image:2zc9.png|left|200px]] | ||
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{{STRUCTURE_2zc9| PDB=2zc9 | SCENE= }} | {{STRUCTURE_2zc9| PDB=2zc9 | SCENE= }} | ||
===Thrombin in complex with Inhibitor=== | ===Thrombin in complex with Inhibitor=== | ||
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{{ABSTRACT_PUBMED_19520086}} | {{ABSTRACT_PUBMED_19520086}} | ||
==About this Structure== | ==About this Structure== | ||
| - | [[2zc9]] is a 3 chain structure of [[Hirudin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZC9 OCA]. | + | [[2zc9]] is a 3 chain structure of [[Hirudin]] and [[Thrombin]] with sequence from [http://en.wikipedia.org/wiki/Hirudo_medicinalis Hirudo medicinalis] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZC9 OCA]. |
==See Also== | ==See Also== | ||
| - | *[[Hirudin]] | + | *[[Hirudin|Hirudin]] |
| + | *[[Thrombin|Thrombin]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:019520086</ref><ref group="xtra">PMID:019409395</ref><references group="xtra"/> |
| + | [[Category: Hirudo medicinalis]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Thrombin]] | [[Category: Thrombin]] | ||
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[[Category: Klebe, G.]] | [[Category: Klebe, G.]] | ||
[[Category: Acute phase]] | [[Category: Acute phase]] | ||
| - | [[Category: Blood clotting | + | [[Category: Blood clotting-hydrolase inhibitor complex]] |
[[Category: Blood clotting/serine protease inhibitor]] | [[Category: Blood clotting/serine protease inhibitor]] | ||
[[Category: Blood coagulation]] | [[Category: Blood coagulation]] | ||
| - | [[Category: Calcium]] | ||
[[Category: Cleavage on pair of basic residue]] | [[Category: Cleavage on pair of basic residue]] | ||
[[Category: Disease mutation]] | [[Category: Disease mutation]] | ||
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[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Kringle]] | [[Category: Kringle]] | ||
| - | [[Category: Pharmaceutical]] | ||
| - | [[Category: Polymorphism]] | ||
[[Category: Secreted]] | [[Category: Secreted]] | ||
[[Category: Sulfation]] | [[Category: Sulfation]] | ||
[[Category: Zymogen]] | [[Category: Zymogen]] | ||
Revision as of 17:43, 25 July 2012
Contents |
Thrombin in complex with Inhibitor
Template:ABSTRACT PUBMED 19520086
About this Structure
2zc9 is a 3 chain structure of Hirudin and Thrombin with sequence from Hirudo medicinalis and Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Baum B, Muley L, Heine A, Smolinski M, Hangauer D, Klebe G. Think twice: understanding the high potency of bis(phenyl)methane inhibitors of thrombin. J Mol Biol. 2009 Aug 21;391(3):552-64. Epub 2009 Jun 9. PMID:19520086 doi:10.1016/j.jmb.2009.06.016
- Baum B, Mohamed M, Zayed M, Gerlach C, Heine A, Hangauer D, Klebe G. More than a simple lipophilic contact: a detailed thermodynamic analysis of nonbasic residues in the s1 pocket of thrombin. J Mol Biol. 2009 Jul 3;390(1):56-69. Epub 2009 May 3. PMID:19409395 doi:10.1016/j.jmb.2009.04.051
Categories: Hirudo medicinalis | Homo sapiens | Thrombin | Baum, B. | Heine, A. | Klebe, G. | Acute phase | Blood clotting-hydrolase inhibitor complex | Blood clotting/serine protease inhibitor | Blood coagulation | Cleavage on pair of basic residue | Disease mutation | Gamma-carboxyglutamic acid | Glycoprotein | Hydrolase | Kringle | Secreted | Sulfation | Zymogen
