1bih
From Proteopedia
(New page: 200px<br /><applet load="1bih" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bih, resolution 3.10Å" /> '''CRYSTAL STRUCTURE OF...) |
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| - | [[Image:1bih.gif|left|200px]]<br /><applet load="1bih" size=" | + | [[Image:1bih.gif|left|200px]]<br /><applet load="1bih" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1bih, resolution 3.10Å" /> | caption="1bih, resolution 3.10Å" /> | ||
'''CRYSTAL STRUCTURE OF THE INSECT IMMUNE PROTEIN HEMOLIN: A NEW DOMAIN ARRANGEMENT WITH IMPLICATIONS FOR HOMOPHILIC ADHESION'''<br /> | '''CRYSTAL STRUCTURE OF THE INSECT IMMUNE PROTEIN HEMOLIN: A NEW DOMAIN ARRANGEMENT WITH IMPLICATIONS FOR HOMOPHILIC ADHESION'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Hemolin, an insect immunoglobulin superfamily member, is a | + | Hemolin, an insect immunoglobulin superfamily member, is a lipopolysaccharide-binding immune protein induced during bacterial infection. The 3.1 angstrom crystal structure reveals a bound phosphate and patches of positive charge, which may represent the lipopolysaccharide binding site, and a new and unexpected arrangement of four immunoglobulin-like domains forming a horseshoe. Sequence analysis and analytical ultracentrifugation suggest that the domain arrangement is a feature of the L1 family of neural cell adhesion molecules related to hemolin. These results are relevant to interpretation of human L1 mutations in neurological diseases and suggest a domain swapping model for how L1 family proteins mediate homophilic adhesion. |
==About this Structure== | ==About this Structure== | ||
| - | 1BIH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Hyalophora_cecropia Hyalophora cecropia] with PO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1BIH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Hyalophora_cecropia Hyalophora cecropia] with <scene name='pdbligand=PO4:'>PO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BIH OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Hyalophora cecropia]] | [[Category: Hyalophora cecropia]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Bjorkman, P | + | [[Category: Bjorkman, P J.]] |
[[Category: Faye, I.]] | [[Category: Faye, I.]] | ||
| - | [[Category: Gastinel, L | + | [[Category: Gastinel, L N.]] |
[[Category: Poon, P.]] | [[Category: Poon, P.]] | ||
| - | [[Category: Su, X | + | [[Category: Su, X D.]] |
| - | [[Category: Vaughn, D | + | [[Category: Vaughn, D E.]] |
[[Category: PO4]] | [[Category: PO4]] | ||
[[Category: homophilic adhesion]] | [[Category: homophilic adhesion]] | ||
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[[Category: lps-binding]] | [[Category: lps-binding]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:55:39 2008'' |
Revision as of 09:55, 21 February 2008
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CRYSTAL STRUCTURE OF THE INSECT IMMUNE PROTEIN HEMOLIN: A NEW DOMAIN ARRANGEMENT WITH IMPLICATIONS FOR HOMOPHILIC ADHESION
Overview
Hemolin, an insect immunoglobulin superfamily member, is a lipopolysaccharide-binding immune protein induced during bacterial infection. The 3.1 angstrom crystal structure reveals a bound phosphate and patches of positive charge, which may represent the lipopolysaccharide binding site, and a new and unexpected arrangement of four immunoglobulin-like domains forming a horseshoe. Sequence analysis and analytical ultracentrifugation suggest that the domain arrangement is a feature of the L1 family of neural cell adhesion molecules related to hemolin. These results are relevant to interpretation of human L1 mutations in neurological diseases and suggest a domain swapping model for how L1 family proteins mediate homophilic adhesion.
About this Structure
1BIH is a Single protein structure of sequence from Hyalophora cecropia with as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of hemolin: a horseshoe shape with implications for homophilic adhesion., Su XD, Gastinel LN, Vaughn DE, Faye I, Poon P, Bjorkman PJ, Science. 1998 Aug 14;281(5379):991-5. PMID:9703515
Page seeded by OCA on Thu Feb 21 11:55:39 2008
