2jg2
From Proteopedia
(New page: 200px<br /> <applet load="2jg2" size="450" color="white" frame="true" align="right" spinBox="true" caption="2jg2, resolution 1.30Å" /> '''HIGH RESOLUTION STR...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2JG2 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/ | + | 2JG2 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Sphingomonas_paucimobilis Sphingomonas paucimobilis]] with MG as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Serine_C-palmitoyltransferase Serine C-palmitoyltransferase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.50 2.3.1.50]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2JG2 OCA]]. |
==Reference== | ==Reference== | ||
The structure of serine palmitoyltransferase; gateway to sphingolipid biosynthesis., Yard BA, Carter LG, Johnson KA, Overton IM, Dorward M, Liu H, McMahon SA, Oke M, Puech D, Barton GJ, Naismith JH, Campopiano DJ, J Mol Biol. 2007 Jul 27;370(5):870-86. Epub 2007 May 10. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17559874 17559874] | The structure of serine palmitoyltransferase; gateway to sphingolipid biosynthesis., Yard BA, Carter LG, Johnson KA, Overton IM, Dorward M, Liu H, McMahon SA, Oke M, Puech D, Barton GJ, Naismith JH, Campopiano DJ, J Mol Biol. 2007 Jul 27;370(5):870-86. Epub 2007 May 10. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17559874 17559874] | ||
| - | [[Category: | + | [[Category: Serine C-palmitoyltransferase]] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
| + | [[Category: Sphingomonas paucimobilis]] | ||
[[Category: Barton, G.J.]] | [[Category: Barton, G.J.]] | ||
[[Category: Campopiano, D.J.]] | [[Category: Campopiano, D.J.]] | ||
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[[Category: transferase]] | [[Category: transferase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:40:16 2007'' |
Revision as of 11:35, 30 October 2007
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HIGH RESOLUTION STRUCTURE OF SPT WITH PLP INTERNAL ALDIMINE
Overview
Sphingolipid biosynthesis commences with the condensation of L-serine and, palmitoyl-CoA to produce 3-ketodihydrosphingosine (KDS). This reaction is, catalysed by the PLP-dependent enzyme serine palmitoyltransferase (SPT; EC, 2.3.1.50), which is a membrane-bound heterodimer (SPT1/SPT2) in eukaryotes, such as humans and yeast and a cytoplasmic homodimer in the Gram-negative, bacterium Sphingomonas paucimobilis. Unusually, the outer membrane of S., paucimobilis contains glycosphingolipid (GSL) instead of, lipopolysaccharide (LPS), and SPT catalyses the first step of the GSL, biosynthetic pathway in this organism. We report here the crystal, structure of the holo-form of S. paucimobilis SPT at 1.3 A resolution. The, enzyme is a symmetrical homodimer with two active sites and a monomeric, ... [(full description)]
About this Structure
2JG2 is a [Single protein] structure of sequence from [Sphingomonas paucimobilis] with MG as [ligand]. Active as [Serine C-palmitoyltransferase], with EC number [2.3.1.50]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
The structure of serine palmitoyltransferase; gateway to sphingolipid biosynthesis., Yard BA, Carter LG, Johnson KA, Overton IM, Dorward M, Liu H, McMahon SA, Oke M, Puech D, Barton GJ, Naismith JH, Campopiano DJ, J Mol Biol. 2007 Jul 27;370(5):870-86. Epub 2007 May 10. PMID:17559874
Page seeded by OCA on Tue Oct 30 13:40:16 2007
Categories: Serine C-palmitoyltransferase | Single protein | Sphingomonas paucimobilis | Barton, G.J. | Campopiano, D.J. | Carter, L.G. | Dorward, M. | Johnson, K.A. | Liu, H. | Mcmahon, S.A. | Naismith, J.H. | Oke, M. | Overton, I.M. | Puech, D. | Yard, B.A. | MG | Plp | Pyridoxal phosphate | Serine palmitoyl transferase | Sphingolipid | Spt | Sspf | Transferase
