This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2x0v
From Proteopedia
m (Protected "2x0v" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
[[Image:2x0v.png|left|200px]] | [[Image:2x0v.png|left|200px]] | ||
| - | <!-- | ||
| - | The line below this paragraph, containing "STRUCTURE_2x0v", creates the "Structure Box" on the page. | ||
| - | You may change the PDB parameter (which sets the PDB file loaded into the applet) | ||
| - | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | ||
| - | or leave the SCENE parameter empty for the default display. | ||
| - | --> | ||
{{STRUCTURE_2x0v| PDB=2x0v | SCENE= }} | {{STRUCTURE_2x0v| PDB=2x0v | SCENE= }} | ||
===STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO 4-(TRIFLUOROMETHYL)BENZENE-1,2-DIAMINE=== | ===STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO 4-(TRIFLUOROMETHYL)BENZENE-1,2-DIAMINE=== | ||
| - | |||
| - | <!-- | ||
| - | The line below this paragraph, {{ABSTRACT_PUBMED_20142040}}, adds the Publication Abstract to the page | ||
| - | (as it appears on PubMed at http://www.pubmed.gov), where 20142040 is the PubMed ID number. | ||
| - | --> | ||
{{ABSTRACT_PUBMED_20142040}} | {{ABSTRACT_PUBMED_20142040}} | ||
==About this Structure== | ==About this Structure== | ||
| - | [[2x0v]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X0V OCA]. | + | [[2x0v]] is a 2 chain structure of [[P53]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X0V OCA]. |
| + | |||
| + | ==See Also== | ||
| + | *[[P53|P53]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:020142040</ref><ref group="xtra">PMID:017015838</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Basse, N.]] | [[Category: Basse, N.]] | ||
Revision as of 18:29, 25 July 2012
Contents |
STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO 4-(TRIFLUOROMETHYL)BENZENE-1,2-DIAMINE
Template:ABSTRACT PUBMED 20142040
About this Structure
2x0v is a 2 chain structure of P53 with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Basse N, Kaar JL, Settanni G, Joerger AC, Rutherford TJ, Fersht AR. Toward the rational design of p53-stabilizing drugs: probing the surface of the oncogenic Y220C mutant. Chem Biol. 2010 Jan 29;17(1):46-56. PMID:20142040 doi:10.1016/j.chembiol.2009.12.011
- Joerger AC, Ang HC, Fersht AR. Structural basis for understanding oncogenic p53 mutations and designing rescue drugs. Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15056-61. Epub 2006 Oct 2. PMID:17015838
Categories: Homo sapiens | Basse, N. | Fersht, A R. | Joerger, A C. | Kaar, J L. | Apoptosis | Cancer | Cell cycle | Host-virus interaction | Li-fraumeni drug discovery | Metal binding | Protein stabilization | Surface crevice | Transcription | Transcription factor | Transcription regulation | Tumor suppressor
