This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1bl0
From Proteopedia
(New page: 200px<br /><applet load="1bl0" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bl0, resolution 2.300Å" /> '''MULTIPLE ANTIBIOTIC...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1bl0.gif|left|200px]]<br /><applet load="1bl0" size=" | + | [[Image:1bl0.gif|left|200px]]<br /><applet load="1bl0" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1bl0, resolution 2.300Å" /> | caption="1bl0, resolution 2.300Å" /> | ||
'''MULTIPLE ANTIBIOTIC RESISTANCE PROTEIN (MARA)/DNA COMPLEX'''<br /> | '''MULTIPLE ANTIBIOTIC RESISTANCE PROTEIN (MARA)/DNA COMPLEX'''<br /> | ||
==Overview== | ==Overview== | ||
| - | A crystal structure for a member of the AraC prokaryotic transcriptional | + | A crystal structure for a member of the AraC prokaryotic transcriptional activator family, MarA, in complex with its cognate DNA-binding site is described. MarA consists of two similar subdomains, each containing a helix-turn-helix DNA-binding motif. The two recognition helices of the motifs are inserted into adjacent major groove segments on the same face of the DNA but are separated by only 27 A thereby bending the DNA by approximately 35 degrees. Extensive interactions between the recognition helices and the DNA major groove provide the sequence specificity. |
==About this Structure== | ==About this Structure== | ||
| - | 1BL0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http:// | + | 1BL0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BL0 OCA]. |
==Reference== | ==Reference== | ||
| Line 14: | Line 14: | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Davies, S.]] | [[Category: Davies, S.]] | ||
| - | [[Category: Martin, J | + | [[Category: Martin, J L.]] |
| - | [[Category: Rhee, R | + | [[Category: Rhee, R G.]] |
| - | [[Category: Rosner, D | + | [[Category: Rosner, D R.]] |
[[Category: transcriptional activator; a bipartite helix-turn-helix protein]] | [[Category: transcriptional activator; a bipartite helix-turn-helix protein]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:56:25 2008'' |
Revision as of 09:56, 21 February 2008
|
MULTIPLE ANTIBIOTIC RESISTANCE PROTEIN (MARA)/DNA COMPLEX
Overview
A crystal structure for a member of the AraC prokaryotic transcriptional activator family, MarA, in complex with its cognate DNA-binding site is described. MarA consists of two similar subdomains, each containing a helix-turn-helix DNA-binding motif. The two recognition helices of the motifs are inserted into adjacent major groove segments on the same face of the DNA but are separated by only 27 A thereby bending the DNA by approximately 35 degrees. Extensive interactions between the recognition helices and the DNA major groove provide the sequence specificity.
About this Structure
1BL0 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
A novel DNA-binding motif in MarA: the first structure for an AraC family transcriptional activator., Rhee S, Martin RG, Rosner JL, Davies DR, Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10413-8. PMID:9724717
Page seeded by OCA on Thu Feb 21 11:56:25 2008
