3d1z

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[[Image:3d1z.png|left|200px]]
[[Image:3d1z.png|left|200px]]
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{{STRUCTURE_3d1z| PDB=3d1z | SCENE= }}
{{STRUCTURE_3d1z| PDB=3d1z | SCENE= }}
===Crystal structure of HIV-1 mutant I54M and inhibitor DARUNAVIR===
===Crystal structure of HIV-1 mutant I54M and inhibitor DARUNAVIR===
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{{ABSTRACT_PUBMED_18597780}}
{{ABSTRACT_PUBMED_18597780}}
==About this Structure==
==About this Structure==
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[[3d1z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D1Z OCA].
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[[3d1z]] is a 2 chain structure of [[Virus protease]] with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D1Z OCA].
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==See Also==
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*[[Virus protease|Virus protease]]
==Reference==
==Reference==
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<ref group="xtra">PMID:18597780</ref><ref group="xtra">PMID:16962136</ref><ref group="xtra">PMID:16277992</ref><references group="xtra"/>
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<ref group="xtra">PMID:018597780</ref><ref group="xtra">PMID:016962136</ref><ref group="xtra">PMID:016277992</ref><references group="xtra"/>
[[Category: HIV-1 retropepsin]]
[[Category: HIV-1 retropepsin]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]

Revision as of 18:41, 25 July 2012

Image:3d1z.png

Template:STRUCTURE 3d1z

Contents

Crystal structure of HIV-1 mutant I54M and inhibitor DARUNAVIR

Template:ABSTRACT PUBMED 18597780

About this Structure

3d1z is a 2 chain structure of Virus protease with sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

See Also

Reference

  • Liu F, Kovalevsky AY, Tie Y, Ghosh AK, Harrison RW, Weber IT. Effect of flap mutations on structure of HIV-1 protease and inhibition by saquinavir and darunavir. J Mol Biol. 2008 Aug 1;381(1):102-15. Epub 2008 Jul 1. PMID:18597780 doi:10.1016/j.jmb.2008.05.062
  • Kovalevsky AY, Liu F, Leshchenko S, Ghosh AK, Louis JM, Harrison RW, Weber IT. Ultra-high resolution crystal structure of HIV-1 protease mutant reveals two binding sites for clinical inhibitor TMC114. J Mol Biol. 2006 Oct 13;363(1):161-73. Epub 2006 Aug 4. PMID:16962136 doi:10.1016/j.jmb.2006.08.007
  • Liu F, Boross PI, Wang YF, Tozser J, Louis JM, Harrison RW, Weber IT. Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S. J Mol Biol. 2005 Dec 9;354(4):789-800. Epub 2005 Oct 21. PMID:16277992 doi:10.1016/j.jmb.2005.09.095

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