1bn0

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(New page: 200px<br /> <applet load="1bn0" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bn0" /> '''SL3 HAIRPIN FROM THE PACKAGING SIGNAL OF HI...)
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'''SL3 HAIRPIN FROM THE PACKAGING SIGNAL OF HIV-1, NMR, 11 STRUCTURES'''<br />
'''SL3 HAIRPIN FROM THE PACKAGING SIGNAL OF HIV-1, NMR, 11 STRUCTURES'''<br />
==Overview==
==Overview==
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An NMR-based structure is presented for a 20 mer hairpin model of the SL3, stem-loop from the HIV-1 packaging signal. The stem has an A-family, structure. However, the GGAG tetraloop appears to be flexible with the, second (G10) and fourth (G12) bases extruded from the normal stacking, arrangement. The A-base (A11) occupies a cavity large enough for it to, jump rapidly between stacking upon G9 (in the loop) and G13 (from the, base-pair adjacent to the loop). The H-bonding loci of G10, A11, and G12, are unoccupied in the free RNA structure. The loop should be easily, adaptable to binding by the HIV-1 nucleocapsid protein or loop receptors.
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An NMR-based structure is presented for a 20 mer hairpin model of the SL3 stem-loop from the HIV-1 packaging signal. The stem has an A-family structure. However, the GGAG tetraloop appears to be flexible with the second (G10) and fourth (G12) bases extruded from the normal stacking arrangement. The A-base (A11) occupies a cavity large enough for it to jump rapidly between stacking upon G9 (in the loop) and G13 (from the base-pair adjacent to the loop). The H-bonding loci of G10, A11, and G12 are unoccupied in the free RNA structure. The loop should be easily adaptable to binding by the HIV-1 nucleocapsid protein or loop receptors.
==About this Structure==
==About this Structure==
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1BN0 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BN0 OCA].
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1BN0 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BN0 OCA].
==Reference==
==Reference==
Three-dimensional folding of an RNA hairpin required for packaging HIV-1., Pappalardo L, Kerwood DJ, Pelczer I, Borer PN, J Mol Biol. 1998 Oct 2;282(4):801-18. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9743628 9743628]
Three-dimensional folding of an RNA hairpin required for packaging HIV-1., Pappalardo L, Kerwood DJ, Pelczer I, Borer PN, J Mol Biol. 1998 Oct 2;282(4):801-18. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9743628 9743628]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: Borer, P.N.]]
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[[Category: Borer, P N.]]
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[[Category: Kerwood, D.J.]]
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[[Category: Kerwood, D J.]]
[[Category: Pappalardo, L.]]
[[Category: Pappalardo, L.]]
[[Category: Pelczer, I.]]
[[Category: Pelczer, I.]]
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[[Category: tetraloop]]
[[Category: tetraloop]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Thu Nov 8 13:54:10 2007''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:56:56 2008''

Revision as of 09:56, 21 February 2008

Image:1bn0.gif

1bn0

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SL3 HAIRPIN FROM THE PACKAGING SIGNAL OF HIV-1, NMR, 11 STRUCTURES

Overview

An NMR-based structure is presented for a 20 mer hairpin model of the SL3 stem-loop from the HIV-1 packaging signal. The stem has an A-family structure. However, the GGAG tetraloop appears to be flexible with the second (G10) and fourth (G12) bases extruded from the normal stacking arrangement. The A-base (A11) occupies a cavity large enough for it to jump rapidly between stacking upon G9 (in the loop) and G13 (from the base-pair adjacent to the loop). The H-bonding loci of G10, A11, and G12 are unoccupied in the free RNA structure. The loop should be easily adaptable to binding by the HIV-1 nucleocapsid protein or loop receptors.

About this Structure

1BN0 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

Three-dimensional folding of an RNA hairpin required for packaging HIV-1., Pappalardo L, Kerwood DJ, Pelczer I, Borer PN, J Mol Biol. 1998 Oct 2;282(4):801-18. PMID:9743628

Page seeded by OCA on Thu Feb 21 11:56:56 2008

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