1bn9
From Proteopedia
(New page: 200px<br /><applet load="1bn9" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bn9" /> '''RESPONSE ELEMENT OF THE ORPHAN NUCLEAR RECEP...) |
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| - | [[Image:1bn9.gif|left|200px]]<br /><applet load="1bn9" size=" | + | [[Image:1bn9.gif|left|200px]]<br /><applet load="1bn9" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1bn9" /> | caption="1bn9" /> | ||
'''RESPONSE ELEMENT OF THE ORPHAN NUCLEAR RECEPTOR REV-ERB BETA'''<br /> | '''RESPONSE ELEMENT OF THE ORPHAN NUCLEAR RECEPTOR REV-ERB BETA'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Rev-erb beta is an orphan receptor that binds as a homodimer or as a | + | Rev-erb beta is an orphan receptor that binds as a homodimer or as a monomer to DNA. The solution structure of the non-palindromic 15 bp DNA duplex d(TAGAATGTAGGTCAG), the response element of Rev-erb beta for monomeric binding, was determined by 1H and 31P NMR, energy minimization with NMR-derived restraints for distances and NOE back-calculation methods. The refined final structures have the typical overall features of B-type DNA. However, titration of this 15 bp duplex with ReDBD, the DNA binding domain of Rev-erb beta, showed large shifts of imino protons and 31P signals, suggesting major conformational changes. |
==About this Structure== | ==About this Structure== | ||
| - | 1BN9 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http:// | + | 1BN9 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BN9 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Delepierre, M.]] | [[Category: Delepierre, M.]] | ||
[[Category: Terenzi, H.]] | [[Category: Terenzi, H.]] | ||
| - | [[Category: Zakin, M | + | [[Category: Zakin, M M.]] |
[[Category: dna]] | [[Category: dna]] | ||
[[Category: orphan nuclear receptor]] | [[Category: orphan nuclear receptor]] | ||
[[Category: response element]] | [[Category: response element]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:57:01 2008'' |
Revision as of 09:57, 21 February 2008
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RESPONSE ELEMENT OF THE ORPHAN NUCLEAR RECEPTOR REV-ERB BETA
Overview
Rev-erb beta is an orphan receptor that binds as a homodimer or as a monomer to DNA. The solution structure of the non-palindromic 15 bp DNA duplex d(TAGAATGTAGGTCAG), the response element of Rev-erb beta for monomeric binding, was determined by 1H and 31P NMR, energy minimization with NMR-derived restraints for distances and NOE back-calculation methods. The refined final structures have the typical overall features of B-type DNA. However, titration of this 15 bp duplex with ReDBD, the DNA binding domain of Rev-erb beta, showed large shifts of imino protons and 31P signals, suggesting major conformational changes.
About this Structure
1BN9 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Solution structure of the orphan nuclear receptor rev-erb beta response element by 1H, 31P NMR and molecular simulation*., Castagne C, Terenzi H, Zakin MM, Delepierre M, Biochimie. 2000 Aug;82(8):739-48. PMID:11018291
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