3l16

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[[Image:3l16.png|left|200px]]
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{{STRUCTURE_3l16| PDB=3l16 | SCENE= }}
{{STRUCTURE_3l16| PDB=3l16 | SCENE= }}
===Discovery of (thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors for the Treatment of Cancer===
===Discovery of (thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors for the Treatment of Cancer===
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{{ABSTRACT_PUBMED_20050669}}
{{ABSTRACT_PUBMED_20050669}}
==About this Structure==
==About this Structure==
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3L16 is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L16 OCA].
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[[3l16]] is a 1 chain structure of [[Phosphoinositide 3-Kinases]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L16 OCA].
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==See Also==
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*[[Phosphoinositide 3-Kinases|Phosphoinositide 3-Kinases]]
==Reference==
==Reference==
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<ref group="xtra">PMID:20050669</ref><references group="xtra"/>
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<ref group="xtra">PMID:020050669</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Phosphatidylinositol-4,5-bisphosphate 3-kinase]]
[[Category: Phosphatidylinositol-4,5-bisphosphate 3-kinase]]
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[[Category: Pi3k-gamma p110 gamma]]
[[Category: Pi3k-gamma p110 gamma]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 17 10:27:58 2010''
 

Revision as of 19:09, 25 July 2012

Image:3l16.png

Template:STRUCTURE 3l16

Contents

Discovery of (thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors for the Treatment of Cancer

Template:ABSTRACT PUBMED 20050669

About this Structure

3l16 is a 1 chain structure of Phosphoinositide 3-Kinases with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Sutherlin DP, Sampath D, Berry M, Castanedo G, Chang Z, Chuckowree I, Dotson J, Folkes A, Friedman L, Goldsmith R, Heffron T, Lee L, Lesnick J, Lewis C, Mathieu S, Nonomiya J, Olivero A, Pang J, Prior WW, Salphati L, Sideris S, Tian Q, Tsui V, Wan NC, Wang S, Wiesmann C, Wong S, Zhu BY. Discovery of (Thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors for the Treatment of Cancer. J Med Chem. 2010 Feb 11;53(3):1086-97. PMID:20050669 doi:10.1021/jm901284w

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