1bqu
From Proteopedia
(New page: 200px<br /> <applet load="1bqu" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bqu, resolution 2.00Å" /> '''CYTOKYNE-BINDING RE...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1bqu.gif|left|200px]]<br /> | + | [[Image:1bqu.gif|left|200px]]<br /><applet load="1bqu" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1bqu" size=" | + | |
caption="1bqu, resolution 2.00Å" /> | caption="1bqu, resolution 2.00Å" /> | ||
'''CYTOKYNE-BINDING REGION OF GP130'''<br /> | '''CYTOKYNE-BINDING REGION OF GP130'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The structure of the cytokine-binding homology region of the cell surface | + | The structure of the cytokine-binding homology region of the cell surface receptor gp130 has been determined by X-ray crystallography at 2.0 A resolution. The beta sandwich structure of the two domains conforms to the topology of the cytokine receptor superfamily. This first structure of an uncomplexed receptor exhibits a similar L-shaped quaternary structure to that of ligand-bound family members and suggests a limited flexibility in relative domain orientation of some 3 degrees. The putative ligand-binding loops are relatively rigid, with a phenylalanine side chain similarly positioned to exposed aromatic residues implicated in ligand binding for other such receptors. The positioning and structure of the N-terminal portion of the polypeptide chain have implications for the structure and function of cytokine receptors, such as gp130, which contain an additional N-terminal immunoglobulin-like domain. |
==About this Structure== | ==About this Structure== | ||
| - | 1BQU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4 and GOL as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1BQU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BQU OCA]. |
==Reference== | ==Reference== | ||
| Line 15: | Line 14: | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Bravo, J.]] | [[Category: Bravo, J.]] | ||
| - | [[Category: Heath, J | + | [[Category: Heath, J K.]] |
| - | [[Category: Jones, E | + | [[Category: Jones, E Y.]] |
[[Category: Staunton, D.]] | [[Category: Staunton, D.]] | ||
[[Category: GOL]] | [[Category: GOL]] | ||
| Line 25: | Line 24: | ||
[[Category: interleukine 6 receptor beta subunit]] | [[Category: interleukine 6 receptor beta subunit]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:58:06 2008'' |
Revision as of 09:58, 21 February 2008
|
CYTOKYNE-BINDING REGION OF GP130
Overview
The structure of the cytokine-binding homology region of the cell surface receptor gp130 has been determined by X-ray crystallography at 2.0 A resolution. The beta sandwich structure of the two domains conforms to the topology of the cytokine receptor superfamily. This first structure of an uncomplexed receptor exhibits a similar L-shaped quaternary structure to that of ligand-bound family members and suggests a limited flexibility in relative domain orientation of some 3 degrees. The putative ligand-binding loops are relatively rigid, with a phenylalanine side chain similarly positioned to exposed aromatic residues implicated in ligand binding for other such receptors. The positioning and structure of the N-terminal portion of the polypeptide chain have implications for the structure and function of cytokine receptors, such as gp130, which contain an additional N-terminal immunoglobulin-like domain.
About this Structure
1BQU is a Single protein structure of sequence from Homo sapiens with and as ligands. Full crystallographic information is available from OCA.
Reference
Crystal structure of a cytokine-binding region of gp130., Bravo J, Staunton D, Heath JK, Jones EY, EMBO J. 1998 Mar 16;17(6):1665-74. PMID:9501088
Page seeded by OCA on Thu Feb 21 11:58:06 2008
