1e0f
From Proteopedia
(New page: 200px<br /> <applet load="1e0f" size="450" color="white" frame="true" align="right" spinBox="true" caption="1e0f, resolution 3.1Å" /> '''CRYSTAL STRUCTURE OF...) |
|||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1E0F is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Haemadipsa_sylvestris Haemadipsa sylvestris]] and [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1E0F OCA]]. | + | 1E0F is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Haemadipsa_sylvestris Haemadipsa sylvestris]] and [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]]. Active as [[http://en.wikipedia.org/wiki/Thrombin Thrombin]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5]]. Structure known Active Site: ATE. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1E0F OCA]]. |
==Reference== | ==Reference== | ||
| Line 15: | Line 15: | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| + | [[Category: Thrombin]] | ||
[[Category: Bode, W.]] | [[Category: Bode, W.]] | ||
[[Category: Fuentes-Prior, P.]] | [[Category: Fuentes-Prior, P.]] | ||
| Line 24: | Line 25: | ||
[[Category: coagulation/crystal structure/heparin-binding site/ hirudin/thrombin inhibitor]] | [[Category: coagulation/crystal structure/heparin-binding site/ hirudin/thrombin inhibitor]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:41:40 2007'' |
Revision as of 11:36, 30 October 2007
|
CRYSTAL STRUCTURE OF THE HUMAN ALPHA-THROMBIN-HAEMADIN COMPLEX: AN EXOSITE II-BINDING INHIBITOR
Overview
The serine proteinase alpha-thrombin plays a pivotal role in the, regulation of blood fluidity, and therefore constitutes a primary target, in the treatment of various haemostatic disorders. Haemadin is a slow, tight- binding thrombin inhibitor from the land-living leech Haemadipsa, sylvestris. Here we present the 3.1 A crystal structure of the human, alpha-thrombin- haemadin complex. The N-terminal segment of haemadin binds, to the active site of thrombin, forming a parallel beta-strand with, residues Ser214-Gly216 of the proteinase. This mode of binding is similar, to that observed in another leech-derived inhibitor, hirudin. In contrast, to hirudin, however, the markedly acidic C-terminal peptide of haemadin, does not bind the fibrinogen-recognition exosite, but interacts with the, ... [(full description)]
About this Structure
1E0F is a [Protein complex] structure of sequences from [Haemadipsa sylvestris] and [Homo sapiens]. Active as [Thrombin], with EC number [3.4.21.5]. Structure known Active Site: ATE. Full crystallographic information is available from [OCA].
Reference
Crystal structure of the human alpha-thrombin-haemadin complex: an exosite II-binding inhibitor., Richardson JL, Kroger B, Hoeffken W, Sadler JE, Pereira P, Huber R, Bode W, Fuentes-Prior P, EMBO J. 2000 Nov 1;19(21):5650-60. PMID:11060016
Page seeded by OCA on Tue Oct 30 13:41:40 2007
