3gyn

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Revision as of 20:47, 25 July 2012

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Template:STRUCTURE 3gyn

Contents 1 Crystal structure of HCV NS5B polymerase with a novel monocyclic dihydropyridinone inhibitor 2 About this Structure 3 See Also 4 Reference

Crystal structure of HCV NS5B polymerase with a novel monocyclic dihydropyridinone inhibitor

Template:ABSTRACT PUBMED 19796938

About this Structure

3gyn is a 2 chain structure of RNA polymerase with sequence from Viruses. Full crystallographic information is available from OCA.

See Also

• RNA polymerase

Reference

• Ellis DA, Blazel JK, Tran CV, Ruebsam F, Murphy DE, Li LS, Zhao J, Zhou Y, McGuire HM, Xiang AX, Webber SE, Zhao Q, Han Q, Kissinger CR, Lardy M, Gobbi A, Showalter RE, Shah AM, Tsan M, Patel RA, LeBrun LA, Kamran R, Bartkowski DM, Nolan TG, Norris DA, Sergeeva MV, Kirkovsky L. 5,5'- and 6,6'-dialkyl-5,6-dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6047-52. Epub 2009 Sep 17. PMID:19796938 doi:10.1016/j.bmcl.2009.09.051