1bvj
From Proteopedia
(New page: 200px<br /> <applet load="1bvj" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bvj" /> '''HIV-1 RNA A-RICH HAIRPIN LOOP'''<br /> ==O...) |
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| - | [[Image:1bvj.gif|left|200px]]<br /> | + | [[Image:1bvj.gif|left|200px]]<br /><applet load="1bvj" size="350" color="white" frame="true" align="right" spinBox="true" |
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'''HIV-1 RNA A-RICH HAIRPIN LOOP'''<br /> | '''HIV-1 RNA A-RICH HAIRPIN LOOP'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Interaction of HIV-1 genomic RNA and human tRNA(Lys)3 initiates viral | + | Interaction of HIV-1 genomic RNA and human tRNA(Lys)3 initiates viral reverse transcription. An adenosine-rich (A-rich) loop in HIV RNA mediates complex formation between tRNA and viral RNA. We have determined the structure of an A-rich loop oligonucleotide using nuclear magnetic resonance spectroscopy. The loop structure is stabilized by a noncanonical G-A pair and a U-turn motif, which leads to stacking of the conserved adenosines. The structure has similarity to the tRNA anticodon structure, and suggests possible mechanisms for its role in initiation of reverse transcription. |
==About this Structure== | ==About this Structure== | ||
| - | 1BVJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Hevea Hevea]. Full crystallographic information is available from [http:// | + | 1BVJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Hevea Hevea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BVJ OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Hevea]] | [[Category: Hevea]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Puglisi, E | + | [[Category: Puglisi, E V.]] |
| - | [[Category: Puglisi, J | + | [[Category: Puglisi, J D.]] |
[[Category: hiv-1 genomic rna]] | [[Category: hiv-1 genomic rna]] | ||
[[Category: reverse transcriptase initiation]] | [[Category: reverse transcriptase initiation]] | ||
[[Category: rna hairpin loop]] | [[Category: rna hairpin loop]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:59:31 2008'' |
Revision as of 09:59, 21 February 2008
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HIV-1 RNA A-RICH HAIRPIN LOOP
Overview
Interaction of HIV-1 genomic RNA and human tRNA(Lys)3 initiates viral reverse transcription. An adenosine-rich (A-rich) loop in HIV RNA mediates complex formation between tRNA and viral RNA. We have determined the structure of an A-rich loop oligonucleotide using nuclear magnetic resonance spectroscopy. The loop structure is stabilized by a noncanonical G-A pair and a U-turn motif, which leads to stacking of the conserved adenosines. The structure has similarity to the tRNA anticodon structure, and suggests possible mechanisms for its role in initiation of reverse transcription.
About this Structure
1BVJ is a Single protein structure of sequence from Hevea. Full crystallographic information is available from OCA.
Reference
HIV-1 A-rich RNA loop mimics the tRNA anticodon structure., Puglisi EV, Puglisi JD, Nat Struct Biol. 1998 Dec;5(12):1033-6. PMID:9846871
Page seeded by OCA on Thu Feb 21 11:59:31 2008
