1ww3

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[[Image:1ww3.png|left|200px]]
[[Image:1ww3.png|left|200px]]
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{{STRUCTURE_1ww3| PDB=1ww3 | SCENE= }}
{{STRUCTURE_1ww3| PDB=1ww3 | SCENE= }}
===Crystallographic studies on two bioisosteric analogues, N-acetyl-beta-D-glucopyranosylamine and N-trifluoroacetyl-beta-D-glucopyranosylamine, potent inhibitors of muscle glycogen phosphorylase===
===Crystallographic studies on two bioisosteric analogues, N-acetyl-beta-D-glucopyranosylamine and N-trifluoroacetyl-beta-D-glucopyranosylamine, potent inhibitors of muscle glycogen phosphorylase===
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{{ABSTRACT_PUBMED_16213146}}
{{ABSTRACT_PUBMED_16213146}}
==About this Structure==
==About this Structure==
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[[1ww3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WW3 OCA].
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[[1ww3]] is a 1 chain structure of [[Glycogen Phosphorylase]] with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WW3 OCA].
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==See Also==
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*[[Glycogen Phosphorylase|Glycogen Phosphorylase]]
==Reference==
==Reference==
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<ref group="xtra">PMID:16213146</ref><ref group="xtra">PMID:8580837</ref><ref group="xtra">PMID:15299833</ref><references group="xtra"/>
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<ref group="xtra">PMID:016213146</ref><ref group="xtra">PMID:008580837</ref><ref group="xtra">PMID:015299833</ref><references group="xtra"/>
[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
[[Category: Phosphorylase]]
[[Category: Phosphorylase]]

Revision as of 22:04, 25 July 2012

Template:STRUCTURE 1ww3

Contents

Crystallographic studies on two bioisosteric analogues, N-acetyl-beta-D-glucopyranosylamine and N-trifluoroacetyl-beta-D-glucopyranosylamine, potent inhibitors of muscle glycogen phosphorylase

Template:ABSTRACT PUBMED 16213146

About this Structure

1ww3 is a 1 chain structure of Glycogen Phosphorylase with sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA.

See Also

Reference

  • Anagnostou E, Kosmopoulou MN, Chrysina ED, Leonidas DD, Hadjiloi T, Tiraidis C, Zographos SE, Gyorgydeak Z, Somsak L, Docsa T, Gergely P, Kolisis FN, Oikonomakos NG. Crystallographic studies on two bioisosteric analogues, N-acetyl-beta-D-glucopyranosylamine and N-trifluoroacetyl-beta-D-glucopyranosylamine, potent inhibitors of muscle glycogen phosphorylase. Bioorg Med Chem. 2006 Jan 1;14(1):181-9. Epub 2005 Oct 4. PMID:16213146 doi:10.1016/j.bmc.2005.08.010
  • Oikonomakos NG, Kontou M, Zographos SE, Watson KA, Johnson LN, Bichard CJ, Fleet GW, Acharya KR. N-acetyl-beta-D-glucopyranosylamine: a potent T-state inhibitor of glycogen phosphorylase. A comparison with alpha-D-glucose. Protein Sci. 1995 Dec;4(12):2469-77. PMID:8580837
  • Watson KA, Mitchell EP, Johnson LN, Cruciani G, Son JC, Bichard CJ, Fleet GW, Oikonomakos NG, Kontou M, Zographos SE. Glucose analogue inhibitors of glycogen phosphorylase: from crystallographic analysis to drug prediction using GRID force-field and GOLPE variable selection. Acta Crystallogr D Biol Crystallogr. 1995 Jul 1;51(Pt 4):458-72. PMID:15299833 doi:10.1107/S090744499401348X

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