1bb6
From Proteopedia
(New page: 200px<br /> <applet load="1bb6" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bb6, resolution 2.0Å" /> '''LYSOZYME COMPLEX WIT...) |
|||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1BB6 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Oncorhynchus_mykiss Oncorhynchus mykiss]] with UMG as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BB6 OCA]]. | + | 1BB6 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Oncorhynchus_mykiss Oncorhynchus mykiss]] with UMG as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Lysozyme Lysozyme]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17]]. Structure known Active Site: NUL. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BB6 OCA]]. |
==Reference== | ==Reference== | ||
Structural studies on the binding of 4-methylumbelliferone glycosides of chitin to rainbow trout lysozyme., Vollan VB, Hough E, Karlsen S, Acta Crystallogr D Biol Crystallogr. 1999 Jan;55(Pt 1):60-6. Epub 1999 Jan, 1. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10089395 10089395] | Structural studies on the binding of 4-methylumbelliferone glycosides of chitin to rainbow trout lysozyme., Vollan VB, Hough E, Karlsen S, Acta Crystallogr D Biol Crystallogr. 1999 Jan;55(Pt 1):60-6. Epub 1999 Jan, 1. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10089395 10089395] | ||
| + | [[Category: Lysozyme]] | ||
[[Category: Oncorhynchus mykiss]] | [[Category: Oncorhynchus mykiss]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| Line 22: | Line 23: | ||
[[Category: umbelliferone glycosides]] | [[Category: umbelliferone glycosides]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:42:59 2007'' |
Revision as of 11:38, 30 October 2007
|
LYSOZYME COMPLEX WITH 4-METHYL-UMBELLIFERYL CHITOTRIOSE
Overview
Two complexes between rainbow trout lysozyme (RBTL) and, 4-methylumbelliferyl chitobioside, 4MeU-(GlcNAc)2, and chitotrioside, 4MeU-(GlcNAc)3, were produced by co-crystallization and soaking, respectively, and the crystal structures were solved at 2.0 A resolution., The results show that 4-MeU-(GlcNAc)3 binds in subsites A-D and that, 4-MeU-(GlcNAc)2 binds in subsites B-D in the active-site cleft of RBTL., This agrees well with earlier crystallographic studies on the binding of, oligosaccharides of chitin to RBTL, which showed that (GlcNAc)3 binds to, sites B-D in RBTL and not to A-C as seen in the human and turkey egg-white, lysozymes. For both complexes the 4-MeU moiety in site D has diffuse, electron density and is flexible, as it is only bound to water molecules, and not to the ... [(full description)]
About this Structure
1BB6 is a [Single protein] structure of sequence from [Oncorhynchus mykiss] with UMG as [ligand]. Active as [Lysozyme], with EC number [3.2.1.17]. Structure known Active Site: NUL. Full crystallographic information is available from [OCA].
Reference
Structural studies on the binding of 4-methylumbelliferone glycosides of chitin to rainbow trout lysozyme., Vollan VB, Hough E, Karlsen S, Acta Crystallogr D Biol Crystallogr. 1999 Jan;55(Pt 1):60-6. Epub 1999 Jan, 1. PMID:10089395
Page seeded by OCA on Tue Oct 30 13:42:59 2007
