2cj5
From Proteopedia
(New page: 200px<br /> <applet load="2cj5" size="450" color="white" frame="true" align="right" spinBox="true" caption="2cj5, resolution 1.84Å" /> '''CRYSTAL STRUCTURE O...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2CJ5 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Nicotiana_tabacum Nicotiana tabacum]] with ACT and SO4 as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CJ5 OCA]]. | + | 2CJ5 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Nicotiana_tabacum Nicotiana tabacum]] with ACT and SO4 as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CJ5 OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: protein binding]] | [[Category: protein binding]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:43:47 2007'' |
Revision as of 11:39, 30 October 2007
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CRYSTAL STRUCTURE OF A CELL WALL INVERTASE INHIBITOR FROM TOBACCO (PH 5.0)
Overview
Plant acid invertases catalyse the breakdown of sucrose. Their activity is, tightly regulated through interaction with specific protein inhibitors., The complex between the cell-wall invertase inhibitor Nt-CIF and its, target enzyme is stable only at acidic pH, as found in the plant cell, wall. Since the pH in this compartment can be modulated between pH 4 and 6, in planta, the rapid dissociation of the inhibitor-enzyme complex at, neutral pH may represent a regulatory event. Here, it is analyzed whether, the inhibitory component undergoes structural rearrangements upon changes, in the pH environment. Six crystal forms grown at pH 4.6-9.5 and, diffracting up to 1.63 Angstrom indicate only small structural changes in, CIF. This suggests that complex dissociation at neutral pH is mediated, ... [(full description)]
About this Structure
2CJ5 is a [Single protein] structure of sequence from [Nicotiana tabacum] with ACT and SO4 as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Multiple crystal forms of the cell-wall invertase inhibitor from tobacco support high conformational rigidity over a broad pH range., Hothorn M, Scheffzek K, Acta Crystallogr D Biol Crystallogr. 2006 Jun;62(Pt 6):665-70. Epub 2006, May 12. PMID:16699194
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