This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1wut
From Proteopedia
(Difference between revisions)
m (Protected "1wut" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
[[Image:1wut.png|left|200px]] | [[Image:1wut.png|left|200px]] | ||
| - | <!-- | ||
| - | The line below this paragraph, containing "STRUCTURE_1wut", creates the "Structure Box" on the page. | ||
| - | You may change the PDB parameter (which sets the PDB file loaded into the applet) | ||
| - | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | ||
| - | or leave the SCENE parameter empty for the default display. | ||
| - | --> | ||
{{STRUCTURE_1wut| PDB=1wut | SCENE= }} | {{STRUCTURE_1wut| PDB=1wut | SCENE= }} | ||
===Acyl Ureas as Human Liver Glycogen Phosphorylase Inhibitors for the Treatment of Type 2 Diabetes=== | ===Acyl Ureas as Human Liver Glycogen Phosphorylase Inhibitors for the Treatment of Type 2 Diabetes=== | ||
| - | |||
| - | <!-- | ||
| - | The line below this paragraph, {{ABSTRACT_PUBMED_15987904}}, adds the Publication Abstract to the page | ||
| - | (as it appears on PubMed at http://www.pubmed.gov), where 15987904 is the PubMed ID number. | ||
| - | --> | ||
{{ABSTRACT_PUBMED_15987904}} | {{ABSTRACT_PUBMED_15987904}} | ||
==About this Structure== | ==About this Structure== | ||
| - | [[1wut]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WUT OCA]. | + | [[1wut]] is a 1 chain structure of [[Glycogen Phosphorylase]] with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WUT OCA]. |
| + | |||
| + | ==See Also== | ||
| + | *[[Glycogen Phosphorylase|Glycogen Phosphorylase]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:015987904</ref><ref group="xtra">PMID:010873856</ref><ref group="xtra">PMID:009384557</ref><ref group="xtra">PMID:010980448</ref><ref group="xtra">PMID:014592521</ref><references group="xtra"/> |
[[Category: Oryctolagus cuniculus]] | [[Category: Oryctolagus cuniculus]] | ||
[[Category: Phosphorylase]] | [[Category: Phosphorylase]] | ||
Revision as of 23:18, 25 July 2012
Contents |
Acyl Ureas as Human Liver Glycogen Phosphorylase Inhibitors for the Treatment of Type 2 Diabetes
Template:ABSTRACT PUBMED 15987904
About this Structure
1wut is a 1 chain structure of Glycogen Phosphorylase with sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA.
See Also
Reference
- Oikonomakos NG, Kosmopoulou MN, Chrysina ED, Leonidas DD, Kostas ID, Wendt KU, Klabunde T, Defossa E. Crystallographic studies on acyl ureas, a new class of glycogen phosphorylase inhibitors, as potential antidiabetic drugs. Protein Sci. 2005 Jul;14(7):1760-71. PMID:15987904 doi:14/7/1760
- Oikonomakos NG, Skamnaki VT, Tsitsanou KE, Gavalas NG, Johnson LN. A new allosteric site in glycogen phosphorylase b as a target for drug interactions. Structure. 2000 Jun 15;8(6):575-84. PMID:10873856
- Zographos SE, Oikonomakos NG, Tsitsanou KE, Leonidas DD, Chrysina ED, Skamnaki VT, Bischoff H, Goldmann S, Watson KA, Johnson LN. The structure of glycogen phosphorylase b with an alkyldihydropyridine-dicarboxylic acid compound, a novel and potent inhibitor. Structure. 1997 Nov 15;5(11):1413-25. PMID:9384557
- Rath VL, Ammirati M, Danley DE, Ekstrom JL, Gibbs EM, Hynes TR, Mathiowetz AM, McPherson RK, Olson TV, Treadway JL, Hoover DJ. Human liver glycogen phosphorylase inhibitors bind at a new allosteric site. Chem Biol. 2000 Sep;7(9):677-82. PMID:10980448
- Lu Z, Bohn J, Bergeron R, Deng Q, Ellsworth KP, Geissler WM, Harris G, McCann PE, McKeever B, Myers RW, Saperstein R, Willoughby CA, Yao J, Chapman K. A new class of glycogen phosphorylase inhibitors. Bioorg Med Chem Lett. 2003 Nov 17;13(22):4125-8. PMID:14592521
Categories: Oryctolagus cuniculus | Phosphorylase | Brachvogel, V. | Burger, H J. | Defossa, E. | Herling, A W. | Kadereit, D. | Klabunde, T. | Kosmopoulou, M N. | Oikonomakos, N G. | Roedern, E von. | Sarubbi, E. | Schmoll, D. | Schonafinger, K. | Wendt, K U. | Glycogenolysis | Transferase | Type 2 diabetes
