2g94

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Revision as of 23:42, 25 July 2012

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Template:STRUCTURE 2g94

Contents 1 Crystal structure of beta-secretase bound to a potent and highly selective inhibitor. 2 About this Structure 3 See Also 4 Reference

Crystal structure of beta-secretase bound to a potent and highly selective inhibitor.

Template:ABSTRACT PUBMED 16620080

About this Structure

2g94 is a 4 chain structure of Beta secretase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• Beta secretase

Reference

• Ghosh AK, Kumaragurubaran N, Hong L, Lei H, Hussain KA, Liu CF, Devasamudram T, Weerasena V, Turner R, Koelsch G, Bilcer G, Tang J. Design, synthesis and X-ray structure of protein-ligand complexes: important insight into selectivity of memapsin 2 (beta-secretase) inhibitors. J Am Chem Soc. 2006 Apr 26;128(16):5310-1. PMID:16620080 doi:10.1021/ja058636j