1cdw
From Proteopedia
(New page: 200px<br /> <applet load="1cdw" size="450" color="white" frame="true" align="right" spinBox="true" caption="1cdw, resolution 1.900Å" /> '''HUMAN TBP CORE DOM...) |
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| - | [[Image:1cdw.gif|left|200px]]<br /> | + | [[Image:1cdw.gif|left|200px]]<br /><applet load="1cdw" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1cdw" size=" | + | |
caption="1cdw, resolution 1.900Å" /> | caption="1cdw, resolution 1.900Å" /> | ||
'''HUMAN TBP CORE DOMAIN COMPLEXED WITH DNA'''<br /> | '''HUMAN TBP CORE DOMAIN COMPLEXED WITH DNA'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The TATA box-binding protein (TBP) is required by all three eukaryotic RNA | + | The TATA box-binding protein (TBP) is required by all three eukaryotic RNA polymerases for correct initiation of transcription of ribosomal, messenger, small nuclear, and transfer RNAs. The cocrystal structure of the C-terminal/core region of human TBP complexed with the TATA element of the adenovirus major late promoter has been determined at 1.9 angstroms resolution. Structural and functional analyses of the protein-DNA complex are presented, with a detailed comparison to our 1.9-angstroms resolution structure of Arabidopsis thaliana TBP2 bound to the same TATA box. |
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1CDW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1CDW with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb67_1.html TATA-Binding Protein]]. Full crystallographic information is available from [http:// | + | 1CDW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1CDW with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb67_1.html TATA-Binding Protein]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CDW OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: TATA-Binding Protein]] | [[Category: TATA-Binding Protein]] | ||
| - | [[Category: Burley, S | + | [[Category: Burley, S K.]] |
[[Category: Chen, H.]] | [[Category: Chen, H.]] | ||
| - | [[Category: Halay, E | + | [[Category: Halay, E D.]] |
[[Category: Hoffmann, A.]] | [[Category: Hoffmann, A.]] | ||
| - | [[Category: Nikolov, D | + | [[Category: Nikolov, D B.]] |
| - | [[Category: Roeder, R | + | [[Category: Roeder, R G.]] |
[[Category: complex (transcription factor/dna)]] | [[Category: complex (transcription factor/dna)]] | ||
[[Category: dna binding]] | [[Category: dna binding]] | ||
[[Category: transcription initiation]] | [[Category: transcription initiation]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:05:05 2008'' |
Revision as of 10:05, 21 February 2008
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HUMAN TBP CORE DOMAIN COMPLEXED WITH DNA
Contents |
Overview
The TATA box-binding protein (TBP) is required by all three eukaryotic RNA polymerases for correct initiation of transcription of ribosomal, messenger, small nuclear, and transfer RNAs. The cocrystal structure of the C-terminal/core region of human TBP complexed with the TATA element of the adenovirus major late promoter has been determined at 1.9 angstroms resolution. Structural and functional analyses of the protein-DNA complex are presented, with a detailed comparison to our 1.9-angstroms resolution structure of Arabidopsis thaliana TBP2 bound to the same TATA box.
Disease
Known diseases associated with this structure: Huntington disease-like-4 OMIM:[600075], Parkinson disease OMIM:[600075], Spinocerebellar ataxia 17 OMIM:[600075]
About this Structure
1CDW is a Single protein structure of sequence from Homo sapiens. The following page contains interesting information on the relation of 1CDW with [TATA-Binding Protein]. Full crystallographic information is available from OCA.
Reference
Crystal structure of a human TATA box-binding protein/TATA element complex., Nikolov DB, Chen H, Halay ED, Hoffman A, Roeder RG, Burley SK, Proc Natl Acad Sci U S A. 1996 May 14;93(10):4862-7. PMID:8643494
Page seeded by OCA on Thu Feb 21 12:05:05 2008
