1cfb
From Proteopedia
(New page: 200px<br /><applet load="1cfb" size="450" color="white" frame="true" align="right" spinBox="true" caption="1cfb, resolution 2.0Å" /> '''CRYSTAL STRUCTURE OF ...) |
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| - | [[Image:1cfb.gif|left|200px]]<br /><applet load="1cfb" size=" | + | [[Image:1cfb.gif|left|200px]]<br /><applet load="1cfb" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1cfb, resolution 2.0Å" /> | caption="1cfb, resolution 2.0Å" /> | ||
'''CRYSTAL STRUCTURE OF TANDEM TYPE III FIBRONECTIN DOMAINS FROM DROSOPHILA NEUROGLIAN AT 2.0 ANGSTROMS'''<br /> | '''CRYSTAL STRUCTURE OF TANDEM TYPE III FIBRONECTIN DOMAINS FROM DROSOPHILA NEUROGLIAN AT 2.0 ANGSTROMS'''<br /> | ||
==Overview== | ==Overview== | ||
| - | We report the crystal structure of two adjacent fibronectin type III | + | We report the crystal structure of two adjacent fibronectin type III repeats from the Drosophila neural cell adhesion molecule neuroglian. Each domain consists of two antiparallel beta sheets and is folded topologically identically to single fibronectin type III domains from the extracellular matrix proteins tenascin and fibronectin. beta bulges and left-handed polyproline II helices disrupt the regular beta sheet structure of both neuroglian domains. The hydrophobic interdomain interface includes a metal-binding site, presumably involved in stabilizing the relative orientation between domains and predicted by sequence comparision to be present in the vertebrate homolog molecule L1. The neuroglian domains are related by a near perfect 2-fold screw axis along the longest molecular dimension. Using this relationship, a model for arrays of tandem fibronectin type III repeats in neuroglian and other molecules is proposed. |
==About this Structure== | ==About this Structure== | ||
| - | 1CFB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster] with NAG, SO4 and NA as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1CFB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster] with <scene name='pdbligand=NAG:'>NAG</scene>, <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=NA:'>NA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CFB OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Drosophila melanogaster]] | [[Category: Drosophila melanogaster]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Bieber, A | + | [[Category: Bieber, A J.]] |
| - | [[Category: Bjorkman, P | + | [[Category: Bjorkman, P J.]] |
| - | [[Category: Huber, A | + | [[Category: Huber, A H.]] |
| - | [[Category: Wang, Y | + | [[Category: Wang, Y E.]] |
[[Category: NA]] | [[Category: NA]] | ||
[[Category: NAG]] | [[Category: NAG]] | ||
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[[Category: neural adhesion molecule]] | [[Category: neural adhesion molecule]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:05:36 2008'' |
Revision as of 10:05, 21 February 2008
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CRYSTAL STRUCTURE OF TANDEM TYPE III FIBRONECTIN DOMAINS FROM DROSOPHILA NEUROGLIAN AT 2.0 ANGSTROMS
Overview
We report the crystal structure of two adjacent fibronectin type III repeats from the Drosophila neural cell adhesion molecule neuroglian. Each domain consists of two antiparallel beta sheets and is folded topologically identically to single fibronectin type III domains from the extracellular matrix proteins tenascin and fibronectin. beta bulges and left-handed polyproline II helices disrupt the regular beta sheet structure of both neuroglian domains. The hydrophobic interdomain interface includes a metal-binding site, presumably involved in stabilizing the relative orientation between domains and predicted by sequence comparision to be present in the vertebrate homolog molecule L1. The neuroglian domains are related by a near perfect 2-fold screw axis along the longest molecular dimension. Using this relationship, a model for arrays of tandem fibronectin type III repeats in neuroglian and other molecules is proposed.
About this Structure
1CFB is a Single protein structure of sequence from Drosophila melanogaster with , and as ligands. Full crystallographic information is available from OCA.
Reference
Crystal structure of tandem type III fibronectin domains from Drosophila neuroglian at 2.0 A., Huber AH, Wang YM, Bieber AJ, Bjorkman PJ, Neuron. 1994 Apr;12(4):717-31. PMID:7512815
Page seeded by OCA on Thu Feb 21 12:05:36 2008
