1dub
From Proteopedia
(New page: 200px<br /> <applet load="1dub" size="450" color="white" frame="true" align="right" spinBox="true" caption="1dub, resolution 2.5Å" /> '''2-ENOYL-COA HYDRATAS...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1DUB is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]] with CAA as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.17 4.2.1.17]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1DUB OCA]]. | + | 1DUB is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]] with CAA as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Enoyl-CoA_hydratase Enoyl-CoA hydratase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.17 4.2.1.17]]. Structure known Active Sites: CR1 and CR2. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1DUB OCA]]. |
==Reference== | ==Reference== | ||
Crystal structure of enoyl-coenzyme A (CoA) hydratase at 2.5 angstroms resolution: a spiral fold defines the CoA-binding pocket., Engel CK, Mathieu M, Zeelen JP, Hiltunen JK, Wierenga RK, EMBO J. 1996 Oct 1;15(19):5135-45. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8895557 8895557] | Crystal structure of enoyl-coenzyme A (CoA) hydratase at 2.5 angstroms resolution: a spiral fold defines the CoA-binding pocket., Engel CK, Mathieu M, Zeelen JP, Hiltunen JK, Wierenga RK, EMBO J. 1996 Oct 1;15(19):5135-45. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8895557 8895557] | ||
| + | [[Category: Enoyl-CoA hydratase]] | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: lyase]] | [[Category: lyase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:45:27 2007'' |
Revision as of 11:40, 30 October 2007
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2-ENOYL-COA HYDRATASE, DATA COLLECTED AT 100 K, PH 6.5
Overview
The crystal structure of rat liver mitochondrial enoyl-coenzyme A (CoA), hydratase complexed with the potent inhibitor acetoacetyl-CoA has been, refined at 2.5 angstroms resolution. This enzyme catalyses the reversible, addition of water to alpha,beta-unsaturated enoyl-CoA thioesters, with, nearly diffusion-controlled reaction rates for the best substrates., Enoyl-CoA hydratase is a hexamer of six identical subunits of 161 kDa, molecular mass for the complex. The hexamer is a dimer of trimers. The, monomer is folded into a right-handed spiral of four turns, followed by, two small domains which are involved in trimerization. Each turn of the, spiral consists of two beta-strands and an alpha-helix. The mechanism for, the hydratase/dehydratase reaction follows a syn-stereochemistry, a, ... [(full description)]
About this Structure
1DUB is a [Single protein] structure of sequence from [Rattus norvegicus] with CAA as [ligand]. Active as [Enoyl-CoA hydratase], with EC number [4.2.1.17]. Structure known Active Sites: CR1 and CR2. Full crystallographic information is available from [OCA].
Reference
Crystal structure of enoyl-coenzyme A (CoA) hydratase at 2.5 angstroms resolution: a spiral fold defines the CoA-binding pocket., Engel CK, Mathieu M, Zeelen JP, Hiltunen JK, Wierenga RK, EMBO J. 1996 Oct 1;15(19):5135-45. PMID:8895557
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