1cjd
From Proteopedia
(New page: 200px<br /><applet load="1cjd" size="450" color="white" frame="true" align="right" spinBox="true" caption="1cjd, resolution 1.85Å" /> '''THE BACTERIOPHAGE PR...) |
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| - | [[Image:1cjd.gif|left|200px]]<br /><applet load="1cjd" size=" | + | [[Image:1cjd.gif|left|200px]]<br /><applet load="1cjd" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1cjd, resolution 1.85Å" /> | caption="1cjd, resolution 1.85Å" /> | ||
'''THE BACTERIOPHAGE PRD1 COAT PROTEIN, P3, IS STRUCTURALLY SIMILAR TO HUMAN ADENOVIRUS HEXON'''<br /> | '''THE BACTERIOPHAGE PRD1 COAT PROTEIN, P3, IS STRUCTURALLY SIMILAR TO HUMAN ADENOVIRUS HEXON'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The unusual bacteriophage PRD1 features a membrane beneath its icosahedral | + | The unusual bacteriophage PRD1 features a membrane beneath its icosahedral protein coat. The crystal structure of the major coat protein, P3, at 1.85 A resolution reveals a molecule with three interlocking subunits, each with two eight-stranded viral jelly rolls normal to the viral capsid, and putative membrane-interacting regions. Surprisingly, the P3 molecule closely resembles hexon, the equivalent protein in human adenovirus. Both viruses also have similar overall architecture, with identical capsid lattices and attachment proteins at their vertices. Although these two dsDNA viruses infect hosts from very different kingdoms, their striking similarities, from major coat protein through capsid architecture, strongly suggest their evolutionary relationship. |
==About this Structure== | ==About this Structure== | ||
| - | 1CJD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_prd1 Enterobacteria phage prd1]. Full crystallographic information is available from [http:// | + | 1CJD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_prd1 Enterobacteria phage prd1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CJD OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Enterobacteria phage prd1]] | [[Category: Enterobacteria phage prd1]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Bamford, D | + | [[Category: Bamford, D H.]] |
| - | [[Category: Bamford, J | + | [[Category: Bamford, J K.H.]] |
| - | [[Category: Benson, S | + | [[Category: Benson, S D.]] |
| - | [[Category: Burnett, R | + | [[Category: Burnett, R M.]] |
[[Category: bacteriophage prd1]] | [[Category: bacteriophage prd1]] | ||
[[Category: coat protein]] | [[Category: coat protein]] | ||
[[Category: jelly roll]] | [[Category: jelly roll]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:06:40 2008'' |
Revision as of 10:06, 21 February 2008
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THE BACTERIOPHAGE PRD1 COAT PROTEIN, P3, IS STRUCTURALLY SIMILAR TO HUMAN ADENOVIRUS HEXON
Overview
The unusual bacteriophage PRD1 features a membrane beneath its icosahedral protein coat. The crystal structure of the major coat protein, P3, at 1.85 A resolution reveals a molecule with three interlocking subunits, each with two eight-stranded viral jelly rolls normal to the viral capsid, and putative membrane-interacting regions. Surprisingly, the P3 molecule closely resembles hexon, the equivalent protein in human adenovirus. Both viruses also have similar overall architecture, with identical capsid lattices and attachment proteins at their vertices. Although these two dsDNA viruses infect hosts from very different kingdoms, their striking similarities, from major coat protein through capsid architecture, strongly suggest their evolutionary relationship.
About this Structure
1CJD is a Single protein structure of sequence from Enterobacteria phage prd1. Full crystallographic information is available from OCA.
Reference
Viral evolution revealed by bacteriophage PRD1 and human adenovirus coat protein structures., Benson SD, Bamford JK, Bamford DH, Burnett RM, Cell. 1999 Sep 17;98(6):825-33. PMID:10499799
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