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2j47
From Proteopedia
(New page: 200px<br /> <applet load="2j47" size="450" color="white" frame="true" align="right" spinBox="true" caption="2j47, resolution 1.98Å" /> '''BACTEROIDES THETAIO...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2J47 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Bacteroides_thetaiotaomicron Bacteroides thetaiotaomicron]] with GDV and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.52 3.2.1.52]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2J47 OCA]]. | + | 2J47 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Bacteroides_thetaiotaomicron Bacteroides thetaiotaomicron]] with GDV and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Beta-N-acetylhexosaminidase Beta-N-acetylhexosaminidase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.52 3.2.1.52]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2J47 OCA]]. |
==Reference== | ==Reference== | ||
Inhibition of O-GlcNAcase by a gluco-configured nagstatin and a PUGNAc-imidazole hybrid inhibitor., Shanmugasundaram B, Debowski AW, Dennis RJ, Davies GJ, Vocadlo DJ, Vasella A, Chem Commun (Camb). 2006 Nov 13;(42):4372-4. Epub 2006 Sep 29. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17057847 17057847] | Inhibition of O-GlcNAcase by a gluco-configured nagstatin and a PUGNAc-imidazole hybrid inhibitor., Shanmugasundaram B, Debowski AW, Dennis RJ, Davies GJ, Vocadlo DJ, Vasella A, Chem Commun (Camb). 2006 Nov 13;(42):4372-4. Epub 2006 Sep 29. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17057847 17057847] | ||
[[Category: Bacteroides thetaiotaomicron]] | [[Category: Bacteroides thetaiotaomicron]] | ||
| + | [[Category: Beta-N-acetylhexosaminidase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Davies, G.J.]] | [[Category: Davies, G.J.]] | ||
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[[Category: pugnac]] | [[Category: pugnac]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:46:06 2007'' |
Revision as of 11:41, 30 October 2007
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BACTEROIDES THETAIOTAOMICRON GH84 O-GLCNACASE IN COMPLEX WITH A IMIDAZOLE-PUGNAC HYBRID INHIBITOR
Overview
Synthesis of a PUGNAc-imidazole hybrid and its characterization as an, inhibitor of human O-GlcNAcase through enzyme kinetics and X-ray, structural analysis.
About this Structure
2J47 is a [Single protein] structure of sequence from [Bacteroides thetaiotaomicron] with GDV and GOL as [ligands]. Active as [Beta-N-acetylhexosaminidase], with EC number [3.2.1.52]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Inhibition of O-GlcNAcase by a gluco-configured nagstatin and a PUGNAc-imidazole hybrid inhibitor., Shanmugasundaram B, Debowski AW, Dennis RJ, Davies GJ, Vocadlo DJ, Vasella A, Chem Commun (Camb). 2006 Nov 13;(42):4372-4. Epub 2006 Sep 29. PMID:17057847
Page seeded by OCA on Tue Oct 30 13:46:06 2007
Categories: Bacteroides thetaiotaomicron | Beta-N-acetylhexosaminidase | Single protein | Davies, G.J. | Dennis, R.J. | GDV | GOL | Enzyme | Gh84 | Imidazole | Inhibition | Inhibitor | O-glcnacase | Pugnac
