2h9h
From Proteopedia
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[[Image:2h9h.png|left|200px]] | [[Image:2h9h.png|left|200px]] | ||
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{{STRUCTURE_2h9h| PDB=2h9h | SCENE= }} | {{STRUCTURE_2h9h| PDB=2h9h | SCENE= }} | ||
===An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors=== | ===An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors=== | ||
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{{ABSTRACT_PUBMED_16860823}} | {{ABSTRACT_PUBMED_16860823}} | ||
==About this Structure== | ==About this Structure== | ||
| - | [[2h9h]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_a_virus Hepatitis a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H9H OCA]. | + | [[2h9h]] is a 2 chain structure of [[Virus protease]] with sequence from [http://en.wikipedia.org/wiki/Hepatitis_a_virus Hepatitis a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H9H OCA]. |
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| + | ==See Also== | ||
| + | *[[Virus protease|Virus protease]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:016860823</ref><ref group="xtra">PMID:016288920</ref><references group="xtra"/> |
[[Category: Hepatitis a virus]] | [[Category: Hepatitis a virus]] | ||
[[Category: Picornain 3C]] | [[Category: Picornain 3C]] | ||
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[[Category: James, M N.]] | [[Category: James, M N.]] | ||
[[Category: Yin, J.]] | [[Category: Yin, J.]] | ||
| - | [[Category: 3c protease]] | ||
| - | [[Category: Catalytic triad]] | ||
[[Category: Episulfide]] | [[Category: Episulfide]] | ||
| - | [[Category: | + | [[Category: Hydrolase-hydrlase inhibitor complex]] |
| - | [[Category: Hydrolase | + | [[Category: Hydrolase-hydrolase inhibitor complex]] |
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[[Category: Methylketone]] | [[Category: Methylketone]] | ||
| - | [[Category: Picornain]] | ||
Revision as of 03:09, 26 July 2012
Contents |
An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors
Template:ABSTRACT PUBMED 16860823
About this Structure
2h9h is a 2 chain structure of Virus protease with sequence from Hepatitis a virus. Full crystallographic information is available from OCA.
See Also
Reference
- Yin J, Cherney MM, Bergmann EM, Zhang J, Huitema C, Pettersson H, Eltis LD, Vederas JC, James MN. An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors. J Mol Biol. 2006 Aug 25;361(4):673-86. Epub 2006 Jul 7. PMID:16860823 doi:10.1016/j.jmb.2006.06.047
- Yin J, Bergmann EM, Cherney MM, Lall MS, Jain RP, Vederas JC, James MN. Dual modes of modification of hepatitis A virus 3C protease by a serine-derived beta-lactone: selective crystallization and formation of a functional catalytic triad in the active site. J Mol Biol. 2005 Dec 9;354(4):854-71. Epub 2005 Oct 14. PMID:16288920 doi:10.1016/j.jmb.2005.09.074
