3h98

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Revision as of 03:20, 26 July 2012

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Template:STRUCTURE 3h98

Contents 1 Crystal structure of HCV NS5b 1b with (1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyrimidine derivative 2 About this Structure 3 See Also 4 Reference

Crystal structure of HCV NS5b 1b with (1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyrimidine derivative

Template:ABSTRACT PUBMED 19500983

About this Structure

3h98 is a 2 chain structure of RNA polymerase with sequence from Viruses. Full crystallographic information is available from OCA.

See Also

• RNA polymerase

Reference

• Wang G, Lei H, Wang X, Das D, Hong J, Mackinnon CH, Coulter TS, Montalbetti CA, Mears R, Gai X, Bailey SE, Ruhrmund D, Hooi L, Misialek S, Rajagopalan PT, Cheng RK, Barker JJ, Felicetti B, Schonfeld DL, Stoycheva A, Buckman BO, Kossen K, Seiwert SD, Beigelman L. HCV NS5B polymerase inhibitors 2: Synthesis and in vitro activity of (1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyridine and azolo[1,5-a]pyrimidine derivatives. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4480-3. Epub 2009 May 9. PMID:19500983 doi:10.1016/j.bmcl.2009.05.022