Template:STRUCTURE 2hyy

(Difference between revisions)

Revision as of 03:26, 26 July 2012

Ligands:

Gene:

ABL1 (Homo sapiens)

Activity:

Related:

1iep, 1fpu

Structural annotation:
Resources:	InterPro : Ipr015015, Ipr000980, Ipr000719, Ipr011009, Ipr001245, Ipr008266, Ipr001452 Pfam : PF07714 UniProt : P00519

Functional annotation:
Cellular component:	cytoplasm nucleus cytoskeleton
Biological process:	actin cytoskeleton organization and biogenesis protein amino acid phosphorylation peptidyl-tyrosine phosphorylation intracellular signaling cascade mismatch repair DNA damage response, signal transduction resulting in induction of apoptosis S-phase-specific transcription in mitotic cell cycle regulation of transcription, DNA-dependent cell adhesion protein modification process
Molecular function:	ATP binding transferase activity protein-tyrosine kinase activity protein C-terminus binding nucleotide binding manganese ion binding magnesium ion binding protein kinase activity kinase activity protein binding DNA binding metal ion binding

Evolutionary conservation:

Toggle Conservation Colors:	Rows = identical sequences:
Further Information:	Caveats, Explanation, Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, PDBsum, RCSB

Coordinates:

save as pdb, mmCIF, xml

@@ Line 1: / Line 1: @@
 {{Structure
 |PDB= {{{PDB}}}|SCENE={{{SCENE|}}}|SIZE={{{SIZE|350}}}|CAPTION={{{CAPTION|[[2hyy]], [[Resolution|resolution]] 2.40&Aring; (<scene name='initialview01'>default scene</scene>)}}}
-|SITE= <scene name='pdbsite=AC1:Binding+Site+For+Residue+Sti+A+600'>AC1</scene>, <scene name='pdbsite=AC2:Binding+Site+For+Residue+Sti+B+600'>AC2</scene>, <scene name='pdbsite=AC3:Binding+Site+For+Residue+Sti+C+600'>AC3</scene> and <scene name='pdbsite=AC4:Binding+Site+For+Residue+Sti+D+600'>AC4</scene>
 |LIGAND= <scene name='pdbligand=STI:4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE'>STI</scene>
 |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span>