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1csn

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(New page: 200px<br /><applet load="1csn" size="450" color="white" frame="true" align="right" spinBox="true" caption="1csn, resolution 2.0&Aring;" /> '''BINARY COMPLEX OF CAS...)
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'''BINARY COMPLEX OF CASEIN KINASE-1 WITH MGATP'''<br />
'''BINARY COMPLEX OF CASEIN KINASE-1 WITH MGATP'''<br />
==Overview==
==Overview==
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The structure of a truncated variant of casein kinase-1 from, Schizosaccharomyces pombe, has been determined in complex with MgATP at, 2.0 A resolution. The model resembles the 'closed', ATP-bound, conformations of the cyclin-dependent kinase 2 and the cAMP-dependent, protein kinase, with clear differences in the structure of surface loops, that impart unique features to casein kinase-1. The structure is of, unphosphorylated, active conformation of casein kinase-1 and the, peptide-binding site is fully accessible to substrate.
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The structure of a truncated variant of casein kinase-1 from Schizosaccharomyces pombe, has been determined in complex with MgATP at 2.0 A resolution. The model resembles the 'closed', ATP-bound conformations of the cyclin-dependent kinase 2 and the cAMP-dependent protein kinase, with clear differences in the structure of surface loops that impart unique features to casein kinase-1. The structure is of unphosphorylated, active conformation of casein kinase-1 and the peptide-binding site is fully accessible to substrate.
==About this Structure==
==About this Structure==
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1CSN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe] with MG, SO4 and ATP as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1CSN OCA].
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1CSN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe] with <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=ATP:'>ATP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CSN OCA].
==Reference==
==Reference==
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[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Cheng, X.]]
[[Category: Cheng, X.]]
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[[Category: Xu, R.M.]]
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[[Category: Xu, R M.]]
[[Category: ATP]]
[[Category: ATP]]
[[Category: MG]]
[[Category: MG]]
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[[Category: phosphotransferase]]
[[Category: phosphotransferase]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 12:43:38 2007''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:09:18 2008''

Revision as of 10:09, 21 February 2008

Image:1csn.gif

1csn, resolution 2.0Å

Drag the structure with the mouse to rotate

BINARY COMPLEX OF CASEIN KINASE-1 WITH MGATP

Overview

The structure of a truncated variant of casein kinase-1 from Schizosaccharomyces pombe, has been determined in complex with MgATP at 2.0 A resolution. The model resembles the 'closed', ATP-bound conformations of the cyclin-dependent kinase 2 and the cAMP-dependent protein kinase, with clear differences in the structure of surface loops that impart unique features to casein kinase-1. The structure is of unphosphorylated, active conformation of casein kinase-1 and the peptide-binding site is fully accessible to substrate.

About this Structure

1CSN is a Single protein structure of sequence from Schizosaccharomyces pombe with , and as ligands. Full crystallographic information is available from OCA.

Reference

Crystal structure of casein kinase-1, a phosphate-directed protein kinase., Xu RM, Carmel G, Sweet RM, Kuret J, Cheng X, EMBO J. 1995 Mar 1;14(5):1015-23. PMID:7889932

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