1tq0
From Proteopedia
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{{STRUCTURE_1tq0| PDB=1tq0 | SCENE= }} | {{STRUCTURE_1tq0| PDB=1tq0 | SCENE= }} | ||
===Crystal structure of the potent anticoagulant thrombin mutant W215A/E217A in free form=== | ===Crystal structure of the potent anticoagulant thrombin mutant W215A/E217A in free form=== | ||
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{{ABSTRACT_PUBMED_15252033}} | {{ABSTRACT_PUBMED_15252033}} | ||
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| - | ==Disease== | ||
| - | Known disease associated with this structure: Dysprothrombinemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176930 176930]], Hyperprothrombinemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176930 176930]], Hypoprothrombinemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176930 176930]] | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[1tq0]] is a 4 chain structure of [[Thrombin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQ0 OCA]. | |
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| + | ==See Also== | ||
| + | *[[Thrombin|Thrombin]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:015252033</ref><ref group="xtra">PMID:015276844</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Thrombin]] | [[Category: Thrombin]] | ||
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[[Category: Waksman, G.]] | [[Category: Waksman, G.]] | ||
[[Category: Anticoagulant]] | [[Category: Anticoagulant]] | ||
| + | [[Category: Blood clotting]] | ||
[[Category: Thrombin]] | [[Category: Thrombin]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 00:59:04 2009'' | ||
Revision as of 03:55, 26 July 2012
Contents |
Crystal structure of the potent anticoagulant thrombin mutant W215A/E217A in free form
Template:ABSTRACT PUBMED 15252033
About this Structure
1tq0 is a 4 chain structure of Thrombin with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Pineda AO, Chen ZW, Caccia S, Cantwell AM, Savvides SN, Waksman G, Mathews FS, Di Cera E. The anticoagulant thrombin mutant W215A/E217A has a collapsed primary specificity pocket. J Biol Chem. 2004 Sep 17;279(38):39824-8. Epub 2004 Jul 13. PMID:15252033 doi:http://dx.doi.org/10.1074/jbc.M407272200
- Nguyen DM, Leila Reynald R, Gittis AG, Lattman EE. X-ray and thermodynamic studies of staphylococcal nuclease variants I92E and I92K: insights into polarity of the protein interior. J Mol Biol. 2004 Aug 6;341(2):565-74. PMID:15276844 doi:10.1016/j.jmb.2004.05.066
