1hez
From Proteopedia
(New page: 200px<br /> <applet load="1hez" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hez, resolution 2.7Å" /> '''ANTIBODY-ANTIGEN COM...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1HEZ is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Finegoldia_magna Finegoldia magna]] and [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with IMD as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HEZ OCA]]. | + | 1HEZ is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Finegoldia_magna Finegoldia magna]] and [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with IMD as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HEZ OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: superantigen]] | [[Category: superantigen]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:47:39 2007'' |
Revision as of 11:42, 30 October 2007
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ANTIBODY-ANTIGEN COMPLEX
Overview
BACKGROUND: Peptostreptococcus magnus protein L (PpL) is a multidomain, bacterial surface protein whose presence correlates with virulence. It, consists of up to five homologous immunoglobulin binding domains that, interact with the variable (VL) regions of kappa light chains found on two, thirds of mammalian antibodies. RESULTS: We refined the crystal structure, of the complex between a human antibody Fab fragment (2A2) and a single, PpL domain (61 residues) to 2.7 A. The asymmetric unit contains two Fab, molecules sandwiching a single PpL domain, which contacts similar VL, framework regions of two light chains via independent interfaces. The, residues contacted on VL are remote from the hypervariable loops. One, PpL-Vkappa interface agrees with previous biochemical data, while the, ... [(full description)]
About this Structure
1HEZ is a [Protein complex] structure of sequences from [Finegoldia magna] and [Homo sapiens] with IMD as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Complex between Peptostreptococcus magnus protein L and a human antibody reveals structural convergence in the interaction modes of Fab binding proteins., Graille M, Stura EA, Housden NG, Beckingham JA, Bottomley SP, Beale D, Taussig MJ, Sutton BJ, Gore MG, Charbonnier JB, Structure. 2001 Aug;9(8):679-87. PMID:11587642
Page seeded by OCA on Tue Oct 30 13:47:39 2007
