This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1d2m
From Proteopedia
(New page: 200px<br /><applet load="1d2m" size="450" color="white" frame="true" align="right" spinBox="true" caption="1d2m, resolution 1.90Å" /> '''UVRB PROTEIN OF THER...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1d2m.jpg|left|200px]]<br /><applet load="1d2m" size=" | + | [[Image:1d2m.jpg|left|200px]]<br /><applet load="1d2m" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1d2m, resolution 1.90Å" /> | caption="1d2m, resolution 1.90Å" /> | ||
'''UVRB PROTEIN OF THERMUS THERMOPHILUS HB8; A NUCLEOTIDE EXCISION REPAIR ENZYME'''<br /> | '''UVRB PROTEIN OF THERMUS THERMOPHILUS HB8; A NUCLEOTIDE EXCISION REPAIR ENZYME'''<br /> | ||
==Overview== | ==Overview== | ||
| - | In the nucleotide excision repair system, UvrB plays a central role in | + | In the nucleotide excision repair system, UvrB plays a central role in damage recognition and DNA incision by interacting with UvrA and UvrC. We have determined the crystal structure of Thermus thermophilus HB8 UvrB at 1.9 A resolution. UvrB comprises four domains, two of which have an alpha/beta structure resembling the core domains of DNA and RNA helicases. Additionally, UvrB has an alpha-helical domain and a domain consisting of antiparallel beta-sheets (beta-domain). The sequence similarity suggests that the beta-domain interacts with UvrA. Based on the distribution of the conserved regions and the structure of the PcrA-DNA complex, a model for the UvrB-DNA complex is proposed. |
==About this Structure== | ==About this Structure== | ||
| - | 1D2M is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus] with BOG and SO4 as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1D2M is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus] with <scene name='pdbligand=BOG:'>BOG</scene> and <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D2M OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of Thermus thermophilus HB8 UvrB protein, a key enzyme of nucleotide excision repair., Nakagawa N, Sugahara M, Masui R, Kato R, Fukuyama K, Kuramitsu S, J Biochem | + | Crystal structure of Thermus thermophilus HB8 UvrB protein, a key enzyme of nucleotide excision repair., Nakagawa N, Sugahara M, Masui R, Kato R, Fukuyama K, Kuramitsu S, J Biochem. 1999 Dec;126(6):986-90. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10578047 10578047] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Thermus thermophilus]] | [[Category: Thermus thermophilus]] | ||
| Line 18: | Line 18: | ||
[[Category: Masui, R.]] | [[Category: Masui, R.]] | ||
[[Category: Nakagawa, N.]] | [[Category: Nakagawa, N.]] | ||
| - | [[Category: RSGI, RIKEN | + | [[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]] |
[[Category: Sugahara, M.]] | [[Category: Sugahara, M.]] | ||
[[Category: BOG]] | [[Category: BOG]] | ||
| Line 27: | Line 27: | ||
[[Category: structural genomics]] | [[Category: structural genomics]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:12:21 2008'' |
Revision as of 10:12, 21 February 2008
|
UVRB PROTEIN OF THERMUS THERMOPHILUS HB8; A NUCLEOTIDE EXCISION REPAIR ENZYME
Overview
In the nucleotide excision repair system, UvrB plays a central role in damage recognition and DNA incision by interacting with UvrA and UvrC. We have determined the crystal structure of Thermus thermophilus HB8 UvrB at 1.9 A resolution. UvrB comprises four domains, two of which have an alpha/beta structure resembling the core domains of DNA and RNA helicases. Additionally, UvrB has an alpha-helical domain and a domain consisting of antiparallel beta-sheets (beta-domain). The sequence similarity suggests that the beta-domain interacts with UvrA. Based on the distribution of the conserved regions and the structure of the PcrA-DNA complex, a model for the UvrB-DNA complex is proposed.
About this Structure
1D2M is a Single protein structure of sequence from Thermus thermophilus with and as ligands. Full crystallographic information is available from OCA.
Reference
Crystal structure of Thermus thermophilus HB8 UvrB protein, a key enzyme of nucleotide excision repair., Nakagawa N, Sugahara M, Masui R, Kato R, Fukuyama K, Kuramitsu S, J Biochem. 1999 Dec;126(6):986-90. PMID:10578047
Page seeded by OCA on Thu Feb 21 12:12:21 2008
Categories: Single protein | Thermus thermophilus | Fukuyama, K. | Kato, R. | Kuramitsu, S. | Masui, R. | Nakagawa, N. | RSGI, RIKEN Structural Genomics/Proteomics Initiative. | Sugahara, M. | BOG | SO4 | Multidomain protein | Riken structural genomics/proteomics initiative | Rsgi | Structural genomics
