1d2z
From Proteopedia
(New page: 200px<br /><applet load="1d2z" size="450" color="white" frame="true" align="right" spinBox="true" caption="1d2z, resolution 2.0Å" /> '''THREE-DIMENSIONAL STR...) |
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| - | [[Image:1d2z.gif|left|200px]]<br /><applet load="1d2z" size=" | + | [[Image:1d2z.gif|left|200px]]<br /><applet load="1d2z" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1d2z, resolution 2.0Å" /> | caption="1d2z, resolution 2.0Å" /> | ||
'''THREE-DIMENSIONAL STRUCTURE OF A COMPLEX BETWEEN THE DEATH DOMAINS OF PELLE AND TUBE'''<br /> | '''THREE-DIMENSIONAL STRUCTURE OF A COMPLEX BETWEEN THE DEATH DOMAINS OF PELLE AND TUBE'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The interaction of the serine/threonine kinase Pelle and adaptor protein | + | The interaction of the serine/threonine kinase Pelle and adaptor protein Tube through their N-terminal death domains leads to the nuclear translocation of the transcription factor Dorsal and activation of zygotic patterning genes during Drosophila embryogenesis. Crystal structure of the Pelle and Tube death domain heterodimer reveals that the two death domains adopt a six-helix bundle fold and are arranged in an open-ended linear array with plastic interfaces mediating their interactions. The Tube death domain has an insertion between helices 2 and 3, and a C-terminal tail making significant and indispensable contacts in the heterodimer. In vivo assays of Pelle and Tube mutants confirmed that the integrity of the major heterodimer interface is critical to the activity of these molecules. |
==About this Structure== | ==About this Structure== | ||
| - | 1D2Z is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster] with EPE as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1D2Z is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster] with <scene name='pdbligand=EPE:'>EPE</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D2Z OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Drosophila melanogaster]] | [[Category: Drosophila melanogaster]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| - | [[Category: Sprang, S | + | [[Category: Sprang, S R.]] |
[[Category: Towb, P.]] | [[Category: Towb, P.]] | ||
| - | [[Category: Wasserman, S | + | [[Category: Wasserman, S A.]] |
[[Category: Xiao, T.]] | [[Category: Xiao, T.]] | ||
[[Category: EPE]] | [[Category: EPE]] | ||
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[[Category: six-helix bundle]] | [[Category: six-helix bundle]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:12:28 2008'' |
Revision as of 10:12, 21 February 2008
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THREE-DIMENSIONAL STRUCTURE OF A COMPLEX BETWEEN THE DEATH DOMAINS OF PELLE AND TUBE
Overview
The interaction of the serine/threonine kinase Pelle and adaptor protein Tube through their N-terminal death domains leads to the nuclear translocation of the transcription factor Dorsal and activation of zygotic patterning genes during Drosophila embryogenesis. Crystal structure of the Pelle and Tube death domain heterodimer reveals that the two death domains adopt a six-helix bundle fold and are arranged in an open-ended linear array with plastic interfaces mediating their interactions. The Tube death domain has an insertion between helices 2 and 3, and a C-terminal tail making significant and indispensable contacts in the heterodimer. In vivo assays of Pelle and Tube mutants confirmed that the integrity of the major heterodimer interface is critical to the activity of these molecules.
About this Structure
1D2Z is a Protein complex structure of sequences from Drosophila melanogaster with as ligand. Full crystallographic information is available from OCA.
Reference
Three-dimensional structure of a complex between the death domains of Pelle and Tube., Xiao T, Towb P, Wasserman SA, Sprang SR, Cell. 1999 Nov 24;99(5):545-55. PMID:10589682
Page seeded by OCA on Thu Feb 21 12:12:28 2008
