1gio
From Proteopedia
(New page: 200px<br /> <applet load="1gio" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gio" /> '''NMR SOLUTION STRUCTURE OF BOVINE ANGIOGENIN...) |
|||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1GIO is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GIO OCA]]. | + | 1GIO is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]]. Structure known Active Site: RIB. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GIO OCA]]. |
==Reference== | ==Reference== | ||
| Line 22: | Line 22: | ||
[[Category: hydrolase angiogenesis]] | [[Category: hydrolase angiogenesis]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:48:49 2007'' |
Revision as of 11:44, 30 October 2007
|
NMR SOLUTION STRUCTURE OF BOVINE ANGIOGENIN, 10 STRUCTURES
Overview
The three-dimensional structure of bovine angiogenin has been determined, using two- and three-dimensional proton NMR spectroscopy. The solution, structure is very close to that recently determined by X-ray diffraction, analysis. This structure appears well defined, even if five loops and one, helix exhibit greater flexibility. Analysis of the active site geometry, confirms the position of the Glu-118 residue which obstructs the, pyrimidine binding site. There is no experimental evidence of an, unobstructed conformation of angiogenin in solution. In addition, it, appears that the Glu-118 and Ser-119 residues and the cell receptor, binding loop may play an important role in the differences of C-terminal, fragment organization and ribonucleolytic activity observed between, angiogenins and ... [(full description)]
About this Structure
1GIO is a [Single protein] structure of sequence from [Bos taurus]. Structure known Active Site: RIB. Full crystallographic information is available from [OCA].
Reference
Solution structure of bovine angiogenin by 1H nuclear magnetic resonance spectroscopy., Lequin O, Albaret C, Bontems F, Spik G, Lallemand JY, Biochemistry. 1996 Jul 9;35(27):8870-80. PMID:8688423
Page seeded by OCA on Tue Oct 30 13:48:49 2007
