1w6k
From Proteopedia
(New page: 200px<br /> <applet load="1w6k" size="450" color="white" frame="true" align="right" spinBox="true" caption="1w6k, resolution 2.1Å" /> '''STRUCTURE OF HUMAN O...) |
|||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1W6K is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with BOG and LAN as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.7 5.4.99.7]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W6K OCA]]. | + | 1W6K is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with BOG and LAN as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Lanosterol_synthase Lanosterol synthase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.7 5.4.99.7]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W6K OCA]]. |
==Reference== | ==Reference== | ||
Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase., Thoma R, Schulz-Gasch T, D'Arcy B, Benz J, Aebi J, Dehmlow H, Hennig M, Stihle M, Ruf A, Nature. 2004 Nov 4;432(7013):118-22. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15525992 15525992] | Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase., Thoma R, Schulz-Gasch T, D'Arcy B, Benz J, Aebi J, Dehmlow H, Hennig M, Stihle M, Ruf A, Nature. 2004 Nov 4;432(7013):118-22. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15525992 15525992] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| + | [[Category: Lanosterol synthase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Aebi, J.]] | [[Category: Aebi, J.]] | ||
| Line 32: | Line 33: | ||
[[Category: steroid biosynthesis]] | [[Category: steroid biosynthesis]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:49:54 2007'' |
Revision as of 11:45, 30 October 2007
|
STRUCTURE OF HUMAN OSC IN COMPLEX WITH LANOSTEROL
Overview
In higher organisms the formation of the steroid scaffold is catalysed, exclusively by the membrane-bound oxidosqualene cyclase (OSC; lanosterol, synthase). In a highly selective cyclization reaction OSC forms lanosterol, with seven chiral centres starting from the linear substrate, 2,3-oxidosqualene. Valuable data on the mechanism of the complex, cyclization cascade have been collected during the past 50 years using, suicide inhibitors, mutagenesis studies and homology modelling., Nevertheless it is still not fully understood how the enzyme catalyses the, reaction. Because of the decisive role of OSC in cholesterol biosynthesis, it represents a target for the discovery of novel anticholesteraemic drugs, that could complement the widely used statins. Here we present two crystal, ... [(full description)]
About this Structure
1W6K is a [Single protein] structure of sequence from [Homo sapiens] with BOG and LAN as [ligands]. Active as [Lanosterol synthase], with EC number [5.4.99.7]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase., Thoma R, Schulz-Gasch T, D'Arcy B, Benz J, Aebi J, Dehmlow H, Hennig M, Stihle M, Ruf A, Nature. 2004 Nov 4;432(7013):118-22. PMID:15525992
Page seeded by OCA on Tue Oct 30 13:49:54 2007
